Advertisement

Lipoxygenase Products and Their Functions in Glomeruli

  • Raymond Ardaillou
  • Laurent Baud
  • Josée Sraer
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 259)

Abstract

Non-esterified arachidonic acid (C20:4) may be oxygenated by three major lipoxygenase pathways. These include the 5-, 12-, and 15-lipoxygenases which stereospecifically insert one oxygen molecule at the 5, 12, and 15 positions of this fatty acid via mechanisms involving hydrogen abstraction. Each of these enzymes converts C20:4 into a number of metabolites which, for many of them, represent essential mediators of inflammation. C20:4 is also the substrate for cyclooxygenase. Glomerular synthesis of the cyclooxygen-ase metabolites, prostaglandins (PG) and thromboxane (TX) and the role of these products on glomerular hemodynamics and the inflammatory injury during glomerular diseases have been extensively studied (1–3). This review will discuss the metabolism of C20:4 to its lipoxygenase products in glomeruli and their effects on glomerular functions. Potential pathophysiological action of these metabolites in glomerular inflammation will also be considered.

Keywords

High Performance Liquid Chromatography Mesangial Cell Lipoxygenase Activity Glomerular Cell Lipoxygenase Product 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    G. Remuzzi, L. Imberti, M. Rossini, C. Morelli, C. Carminati, G.M. Cattaneo, T. Bertani, Increased glomerular thromboxane synthesis as a possible cause of proteinuria in experimental nephrosis, J. Clin. Invest. 75:94–101 (1985).PubMedCrossRefGoogle Scholar
  2. 2.
    J.E. Stork and M.J. Dunn, Hemodynamic role of thromboxane A2 and prostaglandin E2 in glomerulonephritis, J. Pharmacol. Exp. Ther. 233: 672–678 (1985).PubMedGoogle Scholar
  3. 3.
    E.A. Lianos, G.A. Andres, M.J. Dunn, Glomerular prostaglandin and thromboxane synthesis in rat nephrotoxic serum nephritis, J. Clin. Invest. 72:1439–1448 (1983).PubMedCrossRefGoogle Scholar
  4. 4.
    P.Y.K. Wong, P. Westland, M. Hamberg, E. Granstrom, P.H.N. Chuo, B. Samuelsson, ω-hydroxylation of 12-L-hydroxy-5, 8, 10, 14-eicosatetrae-noic acid in human polymorphonuclear leukocytes, J. Biol. Chem. 259: 2683–2686 (1984).PubMedGoogle Scholar
  5. 5.
    B.J. Fitzsimmons, J. Adams, J.F. Evans, Y. Leblanc, J. Rokach, The lipoxins-Stereochemical identification and determination of their biosynthesis, J. Biol. Chem. 260:13008–13012 (1985).PubMedGoogle Scholar
  6. 6.
    S. Shak, H.D. Perez, I.M. Goldstein, A novel dioxygenation product of arachidonic acid possesses potent chemotactic activity for human polymorphonuclear leukocytes, J. Biol. Chem. 258:14948–14953 (1983).PubMedGoogle Scholar
  7. 7.
    B. Samuelsson, Leukotrienes: Mediators of immediate hypersensitivity reactions and inflammation, Science 220:568–575 (1983).PubMedCrossRefGoogle Scholar
  8. 8.
    T. Yoshimoto, R.J. Soberman, R.A. Lewis, K.F. Austen, Isolation and characterization of leukotriene C4 synthetase of rat basophilic leukemia cells, Proc. Natl. Acad. Sci. USA 82:8399–8403 (1985).PubMedCrossRefGoogle Scholar
  9. 9.
    P. Borgeat, S. Picard, P. Vallerand, Transformation of arachidonic acid in leukocytes. Isolation and structural analysis of a novel hydroxy derivative, Prostaglandins and Medicine 6:557–570 (1981).PubMedCrossRefGoogle Scholar
  10. 10.
    S. Shak and I.M. Goldstein, Leukotriene B4 ω-hydroxylase in human polymorphonuclear leukocytes. Partial purification and indentification as a cytochrome P-450, J. Clin. Invest. 76:1218–1228 (1985).PubMedCrossRefGoogle Scholar
  11. 11.
    O. Breuer and S. Hammarström, Enzymatic conversion of leukotriene B4 to 6-trans-leukotriene B4 by rat kidney homogenates, Biochem. Biophys. Res. Comm. 142:667–673 (1987).PubMedCrossRefGoogle Scholar
  12. 12.
    R.A. Lewis and K.F. Austen, The biologically active leukotrienes. Biosynthesis, metabolism, receptors, functions and pharmacology, J. Clin. Invest. 73:889–897 (1984).PubMedCrossRefGoogle Scholar
  13. 13.
    Y. Iino, K. Tachibana, K. Tomita, N. Yoshiyama, S. Tomura, J. Takeuchi, T. Wakabayashi, I. Morita, S. Murota, Effects of 5-lipoxygenase inhibitor (TMK-688) on proteinuria in experimental nephritis, (Abstr.) Kidney Int. 31:273 (1987).Google Scholar
  14. 14.
    J. Sraer, M. Rigaud, M. Bens, H. Rabinovitch, R. Ardaillou, Metabolism of arachidonic acid via the lipoxygenase pathway in human and murine glomeruli, J. Biol. Chem. 258:4325–4330 (1983).PubMedGoogle Scholar
  15. 15.
    K. Jim, A. Hass id, F. Sun, M.J. Dunn, Lipoxygenase activity in rat kidney glomeruli, glomerular epithelial cells and cortical tubules, J. Biol. Chem. 257:10294–10299 (1982).PubMedGoogle Scholar
  16. 16.
    E.A. Lianos, M.A. Rahman, M.J. Dunn, Glomerular arachidonate lipoxygenation in rat nephrotoxic serum nephritis, J. Clin. Invest. 76:1355–1359 (1985).PubMedCrossRefGoogle Scholar
  17. 17.
    L. Baud, J. Hagege, J. Sraer, E. Rondeau, J. Perez, R. Ardaillou, Reactive oxygen production by cultured rat glomerular mesangial cells during phagocytosis is associated with stimulation of lipoxygenase activity, J. Exp. Med. 158:1836–1852 (1983).PubMedCrossRefGoogle Scholar
  18. 18.
    J. Sraer, M. Bens, R. Ardaillou, J.D. Sraer, Sulfidopeptide leukotriene biosynthesis and metabolism by rat glomeruli and papilla, (Abst.) Kidney Int. 29:346 (1986).Google Scholar
  19. 19.
    V. Cattell, J. Smith, H.T. Cook, S. Moneada, J.A. Salmon, Leukotriene B4 synthesis in normal rat glomeruli, (Abstr.) Kidney Int. 27:254 (1985).Google Scholar
  20. 20.
    E.A. Lianos, Glomerular leukotriene biosynthesis and degradation in the rat: Effects of immune injury, (Abstr.) Kidney Int. 29:339 (1986).Google Scholar
  21. 21.
    M.A. Rahman, M. Nakazawa, S.N. Emancipator, M.J. Dunn, Increased leukotriene B4 (LTB4) synthesis in immune injured rat glomeruli, (Abstr.) Kidnev Int. 29:343 (1986).Google Scholar
  22. 22.
    J. Sraer, M. Bens, J.P. Oudinet, R. Ardaillou, Bioconversion of leukotriene C4 by rat glomeruli and papilla, Prostaglandins 31:909–921 (1986).PubMedGoogle Scholar
  23. 23.
    K. Bernström and S. Hammarström, Metabolism of leukotriene D by porcine kidney, J. Biol. Chem. 256:9579–9582 (1981).PubMedGoogle Scholar
  24. 24.
    W. Jubiz, O. Radmark, C. Malmsten, G. Hansson, J.A. Lindgren, J. Palmblad, A.M. Uden, B. Samuelsson, A novel leukotriene produced by stimulation of leukocytes with formylmethionylleucylphenylalanine, J. Biol. Chem. 257:6106–6110 (1982).PubMedGoogle Scholar
  25. 25.
    K.F. Badr, C. Baylis, J.M. Pfeffer, M.A. Pfeffer, R.J. Soberman, R.A. Lewis, K.F. Austen, E.J. Corey, B.M. Brenner, Renal and systemic hemodynamic responses to intravenous infusion of leukotriene C4 in the rat, Circ. Res. 54:492–499 (1984).PubMedCrossRefGoogle Scholar
  26. 26.
    J. Filep, B. Rigter, J. Fröhlich, Vascular and renal effects of leukotriene C4 in conscious rats, Am. J. Physiol. 249:F739–F744 (1985).PubMedGoogle Scholar
  27. 27.
    K.F. Badr, B.M. Brenner, M. Wasserman, I. Ichikawa, Evidence for local glomerular actions of leukotriene Da, (Abstr.) Kidney Int. 29:328 (1986).Google Scholar
  28. 28.
    C.N. Serhan, B. Samuelsson, K.F. Badr, Novel arachidonic acid metabolites with potent glomerular effects, (Abstr.) Kidney Int. 31:286 (1987).Google Scholar
  29. 29.
    B.J. Ballerman, R.A. Lewis, E.J. Corey, K.F. Austen, B.M. Brenner, Identification and characterization of leukotriene C4 receptors in isolated rat renal glomeruli, Circ. Res. 56:324–330 (1985).CrossRefGoogle Scholar
  30. 30.
    L. Baud, J. Sraer, J. Perez, M.P. Nivez, R. Ardaillou, Leukotriene C4 binds to human glomerular epithelial cells and promotes their proliferation in vitro, J. Clin. Invest. 76:374–377 (1985).PubMedCrossRefGoogle Scholar
  31. 31.
    R. Barnett, P. Goldwasser, L.A. Scharschmidt, D. Schlondorff, Effects of leukotrienes on isolated rat glomeruli and cultured mesangial cells, Am. J. Phvsiol. 250 :F838–F844 (1986).Google Scholar
  32. 32.
    M.S. Simonson and M.J. Dunn, Leukotrienes C4 and D4 contract rat glomerular mesangial cells, Kidnev Int. 30:524–531 (1986).CrossRefGoogle Scholar
  33. 33.
    R. Lacave, F. Delarue, E. Rondeau, J.D. Sraer, 5- and 12-hydroperoxyeico-satetraenoic acids promote contraction of cultured glomerular visceral epithelial cells, (Abstr.) Kidnev Int. 27:339 (1986).Google Scholar
  34. 34.
    R. Ardaillou, L. Baud, D. Chansel, J. Sraer, The role of lipoxygenase products of arachidonate metabolism in the control of glomerular functions, Proceedings of the Xth International Congress of Nephrology, Transmedia Europe Ltd, London, in press (1987).Google Scholar
  35. 35.
    L. Baud, J. Sraer, F. Delarue, M. Bens, F. Balavoine, D. Schlondorff, R. Ardaillou, J.D. Sraer, Lipoxygenase products mediate the attachment of rat macrophages to glomeruli in vitro. Kidney Int. 27:855–863 (1985).PubMedCrossRefGoogle Scholar
  36. 36.
    J. Sraer, L. Baud, M. Bens, E. Podjarny, D. Schlondorff, R. Ardaillou, J.D. Sraer, Glomeruli cooperate with macrophages in converting arachi-donic acid to prostaglandins and hydroxyeicosatetraenoic acids, Prostaglandins Leukotrienes Med. 13:67–74 (1984).CrossRefGoogle Scholar
  37. 37.
    I. Koyama, H. Yamagami, T. Kuwal, M. Kurata, Release of 6-keto prostaglandin F and thromboxane B2 from mouse peritoneal macrophages during their adhesion and spreading on a glass surface, Prostaglandins 23:777–785 (1982).PubMedGoogle Scholar
  38. 38.
    J. Maclouf, B. Fruteau de Laclos, P. Borgeat, Stimulation of leukotriene biosynthesis in human blood leukocytes by platelet-derived 12-hydro-peroxyeicosatetraenoic acid, Proc. Natl. Acad. Sci. (USA) 79:6044–6046 (1982).CrossRefGoogle Scholar
  39. 39.
    R. Lorenzet, J. Niemetz, A.J. Marcus, M.J. Broeckman, Enhancement of mononuclear procoagulant activity by platelet 12-hydroxyeicosatetraenoic acid, J. Clin. Invest. 78:418–423 (1986).PubMedCrossRefGoogle Scholar
  40. 40.
    L. Baud, J. Perez, R. Ardaillou, Dexamethasone and hydrogen peroxide production by mesangial cells during phagocytosis, Am. J. Physiol. 250: F596–F604 (1986).PubMedGoogle Scholar
  41. 41.
    K. Kragballe, L. Desjaríais, J.J. Voorhers, Leukotrienes B4, C4, D4 stimulate DNA synthesis in cultured human epidermal keratinocytes, Brit. J. Dermatol. 113:43–52 (1985).CrossRefGoogle Scholar
  42. 42.
    P. Mené, H.E. Abboud, G.R. Dubyak, P. Dicorleto, A. Scarpa, M.J. Dunn, Platelet-derived growth factor modulates contraction and cytosolic free calcium in cultured mesangial cells, (Abstr.) Kidney Int. 31:175 (1987).Google Scholar
  43. 43.
    P. Tsivitse, H.E. Abboud, C. Saunders, T.C. Knauss, Effect of epidermal growth factor on cultured mesangial cells, (Abstr.) Kidney Int. 31: 184 (1987).Google Scholar
  44. 44.
    L. Baud, J. Perez, M. Denis, R. Ardaillou, Modulation of fibroblast proliferation by sulfidopeptide leukotrienes: Effect of indomethacin, J. Immunology 138:1190–1195 (1987).Google Scholar
  45. 45.
    H.M. Sarau, S. Mong, J.J. Foley, H.L. Wu, S.T. Crooke, Identification and characterization of leukotriene D4 receptors and signal transduction processes in rat basophilic leukemia cells, J. Biol. Chem. 262:4034–4041 (1987).PubMedGoogle Scholar
  46. 46.
    E.J. Goetzl, B.A. Burrall, L. Baud, K.H. Scriven, J.D. Levine, C.H. Koo, Generation and recognition of leukotriene mediators of hypersensitivity and inflammation, Dig. Pis. Sci., in press (1987).Google Scholar
  47. 47.
    G. L’Allemain, A. Franchi, E. Cragoe Jr., J. Pouyssegur, Blockade of the Na+/H+ antiport abolishes growth factor-induced DNA synthesis in fibroblasts, J. Biol. Chem. 259: 4313–4319 (1984).PubMedGoogle Scholar
  48. 48.
    K.F. Badr, V.E. Kelley, H.G. Rennke, B.M. Brenner, Roles for thromboxane A2 and leukotrienes in endotoxin-induced acute renal failure, Kidnev Int. 30:474–480 (1986).CrossRefGoogle Scholar
  49. 49.
    M. Schambelan, S. Blake, J. Sraer, M. Bens, M.P. Nivez, F. Wahbe, Increased prostaglandin production by glomeruli isolated from rats with streptozotocin-induced diabetes mellitus, J. Clin. Invest. 75:404–412 (1985).PubMedCrossRefGoogle Scholar
  50. 50.
    G. Friedlander, L. Moulonguet-Doleris, O. Kourilsky, O. Nussaume, R. Ardaillou, J.D. Sraer, Prostaglandin synthesis by glomeruli isolated from normal and chronically-rejected kidneys, Contr. Nephrol. 41:20–22 (1984).Google Scholar
  51. 51.
    E.A. Lianos, Leukotriene synthesis in nephrotoxic serum nephritis: Role of complement and polymorphonuclear leukocytes, (Abstr.) Clin. Res. 34:972A (1986).Google Scholar
  52. 52.
    M.A. Rahman, M. Nakazawa, S.N. Emancipator, M.J. Dunn, Increased leukotriene B4 synthesis in immune injured rat glomeruli, (Abstr.) Kidnev Int. 29:343 (1986).Google Scholar
  53. 53.
    E.A. Lianos and B. Noble, Glomerular arachidonate 5-lipoxygenation in active and passive Heymann nephritis, (Abstr.) Kidney Int. 31:277 (1987).Google Scholar
  54. 54.
    G.F. Schreiner and E-.R. Unanue, Origin of the rat mesangial phagocyte and its expression of the leukocyte common antigen, Lab. Invest. 51: 515–523 (1984).PubMedGoogle Scholar
  55. 55.
    G.F. Schreiner, R.S. Cotran, E.R. Unanue, Modulation of la and leukocyte common antigen expression in rat glomeruli during the course of glomerulonephritis and aminonucleoside nephrosis, Lab. Invest. 51:524–533 (1984).PubMedGoogle Scholar
  56. 56.
    M.J.H. Smith, A.W. Ford-Hutchinson, M.A. Bray, Leukotriene B4: A potent mediator of inflammation, J. Pharm. Pharmacol. 32:517–518 (1980).PubMedCrossRefGoogle Scholar
  57. 57.
    S.A. Rae and M.J.H. Smith, The stimulation of lysosomal enzyme secretion from human polymorphonuclear leukocytes by leukotriene B4, J. Pharm. Pharmacol. 33:616–617 (1981).PubMedCrossRefGoogle Scholar
  58. 58.
    M.A. Rahman, S.N. Emancipator, M.J. Dunn, Immune complex effects on glomerular eicosanoid production and renal hemodynamics, Kidney Int. 31:1317–1326 (1987).PubMedCrossRefGoogle Scholar
  59. 59.
    W.F. Stenson, K. Chang, J.R. Williamson, Tissue differences in vascular permeability induced by leukotriene B4 and prostaglandin E2 in the rat, Prostaglandins 32:5–17 (1986).PubMedGoogle Scholar
  60. 60.
    L. Baud and R. Ardaillou, Reactive oxygen species: Production and role in the kidney, Am. J. Physiol. 251:F765–F776 (1986).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Raymond Ardaillou
    • 1
  • Laurent Baud
    • 1
  • Josée Sraer
    • 1
  1. 1.INSERM 64Hôpital TenonParisFrance

Personalised recommendations