Lipoxygenase Products and Their Functions in Glomeruli

  • Raymond Ardaillou
  • Laurent Baud
  • Josée Sraer
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 259)


Non-esterified arachidonic acid (C20:4) may be oxygenated by three major lipoxygenase pathways. These include the 5-, 12-, and 15-lipoxygenases which stereospecifically insert one oxygen molecule at the 5, 12, and 15 positions of this fatty acid via mechanisms involving hydrogen abstraction. Each of these enzymes converts C20:4 into a number of metabolites which, for many of them, represent essential mediators of inflammation. C20:4 is also the substrate for cyclooxygenase. Glomerular synthesis of the cyclooxygen-ase metabolites, prostaglandins (PG) and thromboxane (TX) and the role of these products on glomerular hemodynamics and the inflammatory injury during glomerular diseases have been extensively studied (1–3). This review will discuss the metabolism of C20:4 to its lipoxygenase products in glomeruli and their effects on glomerular functions. Potential pathophysiological action of these metabolites in glomerular inflammation will also be considered.


High Performance Liquid Chromatography Mesangial Cell Lipoxygenase Activity Glomerular Cell Lipoxygenase Product 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Raymond Ardaillou
    • 1
  • Laurent Baud
    • 1
  • Josée Sraer
    • 1
  1. 1.INSERM 64Hôpital TenonParisFrance

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