Skip to main content
SpringerLink
Log in

Studies of Renal Eicosanoid Synthesis In Vivo and In Vitro

  • Chapter
Renal Eicosanoids

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 259))

Abstract

The kidney is a rich source of cyclooxygenase and lipoxygenase enzymes which catalyze the conversion of arachidonic acid to prostaglandins (PGs), thromboxane (Tx) and leukotrienes. These eicosanoids are autacoids which have been shown to have biologic actions in vitro and in vivo. Although the biochemical analysis of renal eicosanoids in vitro has been easily accomplished, their identification and quantification in vivo have been shown to be more complex. The present chapter describes some analytic methodologies for the study of the renal eicosanoid system, both in vitro and in vivo. In vitro studies of eicosanoid synthesis by glomerular cells in response to injury will be addressed. In vivo measurement of primary (unmetabolized) PGs and Tx in humans and clinical conditions and pharmacological evidence in favor of a renal origin of the urinary PGI2 breakdown product, i.e., 6-keto-PGF1α and TxB2, will be discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. D. Schlondorff and R. Ardaillou, Prostaglandin and other arachidonic acid metabolites in the kidney, Kidney Int. 29:108–119 (1986).

    PubMed  CAS  Google Scholar 

  2. R.A. Stahl, M. Paravicini, P. Schollmeyer, Angiotensin II stimulation of PGE2 and 6-keto-PGF1α formation by isolated human glomeruli, Kidnev Int. 26:30–34 (1984).

    CAS  Google Scholar 

  3. J. Sraer, N. Ardaillou, J.D. Sraer, R. Ardaillou, In vitro prostaglandin synthesis by human glomeruli and papillae, Prostaglandins 23:855–864 (1983).

    Google Scholar 

  4. A. Hassid, M. Konieczkowski, M.J. Dunn, Prostaglandin synthesis in isolated rat kidney glomeruli, Proc. Natl. Acad. Sci. USA 76:1155–1159 (1979).

    PubMed  CAS  Google Scholar 

  5. J. Sraer, J.D. Sraer, D. Chansel, F. Russo-Marie, B. Kouznetzova, R. Ardaillou, Prostaglandin synthesis by isolated rat renal glomeruli, Mol. Cell Endocrinol. 16:29–37 (1979).

    PubMed  CAS  Google Scholar 

  6. A.S. Petrulis, M. Aikawa, M.J. Dunn, Prostaglandin and thromboxane synthesis by rat glomerular epithelial cells, Kidney Int. 20:469–474 (1981).

    PubMed  CAS  Google Scholar 

  7. J. Sraer, J. Foidart, D. Chansel, P. Mahieu, B. Kouznetzova, R. Ardaillou, Prostaglandin synthesis by mesangial and epithelial glomerular cultured cells, FEBS Letters 15:420–424 (1979).

    Google Scholar 

  8. J.I. Kreisberg, M.J. Karnowsky, L. Levine, Prostaglandin production by homogeneous cultures of rat glomerular epithelial and mesangial cells, Kidney Int. 22:355–359 (1982).

    PubMed  CAS  Google Scholar 

  9. L.A. Scharschmidt and M.J. Dunn, Prostaglandin synthesis by rat glomerular mesangial cells in culture. Effects of angiotensin II and argi-nine vasopressin, J. Clin. Invest. 71:1756–1764 (1983).

    PubMed  CAS  Google Scholar 

  10. N. Ardaillou, Y. Hagege, M.P. Nivez, R. Ardaillou, D. Schlondorff, Vasoconstrictor-evoked prostaglandin synthesis in cultured human mesangial cells, Am. J. Physiol. 248:F240–F246 (1985).

    PubMed  CAS  Google Scholar 

  11. N. Ardaillou, M.P. Nivez, G. Striker, R. Ardaillou, Prostaglandin synthesis by human glomerular cells in culture, Prostaglandins 26:778–784 (1983).

    Google Scholar 

  12. D. Lovett, G.M. Hansen, K. Resch, D. Gemsa, Activation of glomerular mesangial cells by terminal complement components: stimulation of prostanoid and interleukin 1-like factor release, (abstract), Immunobiol. 168:34–35 (1984).

    Google Scholar 

  13. G.M. Hansen, K. Rother, J. Gunther, S. Filsinger, R.B. Sterzel, Terminal complement components stimulate prostanoid production of cultured glomerular epithelial cells, (abstract), Kidney Int. 29:277 (1986).

    Google Scholar 

  14. L. Baud, M.P. Nivez, D. Chansel, R. Ardaillou, Stimulation by oxygen free radicals of prostaglandin production by rat renal glomeruli, Kidney Int. 20:332–345 (1981).

    PubMed  CAS  Google Scholar 

  15. D. Schlondorff, J.A. Satriano, J. Hagege, J. Perez, L. Baud, Effect of platelet activating factor and serum-treated zymosan on prostaglandin E2 synthesis, arachidonic acid release, and contraction of cultured rat mesangial cells, J. Clin. Invest. 73:1227–1231 (1984).

    PubMed  CAS  Google Scholar 

  16. D. Lovett, D. Gemsa, K. Resch, Stimulation of mesangial cell prostanoid secretion by interleukin 1, (abstract), Kidney Int. 19:282 (1986).

    Google Scholar 

  17. J.E. Stork, M.A. Rahman, M.J. Dunn, Eicosanoids in experimental and human renal disease, Am. J. Med. 80 (suppl.1A): 34–35 (1986).

    PubMed  CAS  Google Scholar 

  18. M.W. Sciler, M.A. Venkatachalam, R.S. Contran, Glomerular epithelium: structural alterations induced by polycations, Science 189:390–393 (1975).

    Google Scholar 

  19. W.M. Deen, B.D. Myers, B.M. Brenner, The glomerular barrier to macromolecules: theoretical and experimental considerations, in: “Contemporary Issues In Nephrology,” B.M. Brenner and J.H. Stein, eds., Churchill Livingstone, New York, Vol. 9, pp. 1–29 (1982).

    Google Scholar 

  20. B.M. Brenner, T.H. Hostetter, D. Humes, Molecular basis of proteinuria of glomerular origin, N. Engl. J. Med. 298:826–833 (1978).

    PubMed  CAS  Google Scholar 

  21. E.B. Blau and J.E. Haas, Glomerular sialic acid and proteinuria in human renal disease, Lab. Investu 28:477–481 (1973).

    CAS  Google Scholar 

  22. D. Kerjaschki, A.T. Vernillo, M.G. Farquhar, Reduced sialylation of podocalixin — the major sialoprotein of the rat kidney glomerulus — in aminonucleoside nephrosis, Am. J. Pathol. 118:343–349 (1985).

    PubMed  CAS  Google Scholar 

  23. R.L. Vernier, D.J. Klein, S.P. Sisson, J.D. Mahan, T.R. Oegema, D.M. Brown, Heparan sulfate-rich anionic sites in the human glomerular basement membrane. Decreased concentration in congenital nephrotic syndrome, N. Engl. J. Med. 309:1001–1009 (1983).

    PubMed  CAS  Google Scholar 

  24. J.B. Foidart, Y.S. Picard, R.J. Winaud, P.R. Mahieu, Tissue culture of normal rat glomeruli: glycosaminoglycan biosynthesis by homogenous epithelial and mesangial cell populations, Renal Physiol. 3:169–173 (1980).

    PubMed  CAS  Google Scholar 

  25. J.L. Barnes, S.P. Levine, M.A. Venkatachaiam, Binding of platelet factor four (PF4) to glomerular polyanions, Kidney Int. 25:759–765 (1984).

    PubMed  CAS  Google Scholar 

  26. L. Jorgensen, M.F. Glynn, T. Hovig, E.A. Murphy, M.R. Buchanan, J.F. Mustard, Renal lesions and rise in blood pressure caused by adenosine diphosphate-induced platelet aggregation in rabbits, Lab. Invest. 23: 347–357 (1970).

    PubMed  CAS  Google Scholar 

  27. J.L. Olson, Role of heparin as a protective agent following reduction of renal mass, Kidney Int. 25:376–382 (1984).

    PubMed  CAS  Google Scholar 

  28. J.I. Kreisberg, R.L. Hoover, M.J. Karnowsky, Isolation and characterization of rat glomerular epithelial cells in vitro, Kidney Int. 14:21–30 (1978).

    PubMed  CAS  Google Scholar 

  29. A.K. Singh, B.S. Kasinath, E.J. Lewis, Discrete anionic domains on the surface of glomerular epithelial cells (GEC) (abstract), Clin. Res. 34:609A (1986).

    Google Scholar 

  30. G. Remuzzi, L. Imberti, M. Rossini, C. Morelli, C. Carminati, M.G. Cattaneo, T. Bertani, Increased glomerular thromboxane synthesis as a possible cause of proteinuria in experimental nephrosis, J. Clin. Invest. 75:94–101 (1985).

    PubMed  CAS  Google Scholar 

  31. L.J. Rosenzweig and Y.S. Kanvar, Removal of sulphated (heparan sulphate) or nonsulphated (hyaluronic acid) glycosaminoglycans results in increased permeability of the glomerular basement membrane to 125I-bovine serum albumin, Lab. Invest. 47:177–184 (1982).

    PubMed  CAS  Google Scholar 

  32. V.M. Vehaskari, E.R. Root, F.G. Germuth, A.M. Robson, Glomerular charge and urinary protein excretion: effects of systemic and intrarenal polycation infusion in the rat, Kidney Int. 22:127–135 (1982).

    PubMed  CAS  Google Scholar 

  33. W.T. Shier, D. Dubourdieu, J.P. Durkin, Polycations as prostaglandin synthesis inducers. Stimulation of arachidonic acid release and prostaglandin synthesis in cultured fibroblasts by poly(L-lysine) and other synthetic polycations, Biochim. Biophys. Acta 793:238–250 (1984).

    PubMed  CAS  Google Scholar 

  34. R.A. Stahl, M. Kudelka, M. Paravicini, P. Schollmeyer, Prostaglandin and thromboxane formation in glomeruli from rats with reduced renal mass, Nephron 42:252–257 (1986).

    PubMed  CAS  Google Scholar 

  35. T.H. Hostetter, J.L. Olson, H.G. Rennke, M.A. Venkatachalam, B.M. Brenner, Hyperfiltration in remnant nephrons: a potentially adverse response to renal ablation, Am. J. Physiol. 241:F85–F93 (1981).

    PubMed  CAS  Google Scholar 

  36. M. Schambelan, S. Blake, J. Sraer, M. Beres, M.P. Nivez, F. Wahbe, Increased prostaglandin production by glomeruli isolated from rats with streptozotocin-induced diabetes mellitus, J. Clin. Invest. 75:404–412 (1985).

    PubMed  CAS  Google Scholar 

  37. T.H. Hostetter, J.L. Troy, B.M. Brenner, Glomerular hemodynamics in experimental diabetes mellitus, Kidney Int. 19:410–415 (1981).

    PubMed  CAS  Google Scholar 

  38. I.M. Goldstein, C.L. Malmsten, H. Kindhal, H.B. Kaplan, D. Radmark, B. Samuelsson, G. Weisman, Thromboxane generation by human peripheral blood polymorphonuclear leukocytes, J. Exp. Med. 148:787–792 (1979).

    Google Scholar 

  39. J. Morley, M.A. Bray, R.W. Jones, D.H. Nugteren, D.A. Van Dorp, Prostaglandin and thromboxane production by human and guinea-pig macrophages and leukocytes, Prostaglandins 17:730–736 (1979).

    Google Scholar 

  40. P.S. Needleman, S. Moneada, S. Bunting, J.R. Vane, M. Hamberg, B. Samuelsson, Identification of an enzyme in platelet microsomes which generates thromboxane A2 from prostaglandin endoperoxides, Nature 261:558–560 (1976).

    PubMed  CAS  Google Scholar 

  41. J.I. Kreisberg, D.B. Wayne, M.J. Karnowsky, Rapid and focal loss of negative charge associated with mononuclear cell infiltration early in nephrotoxic serum nephritis, Kidney Int. 16:290–300 (1979).

    PubMed  CAS  Google Scholar 

  42. E.A. Lianos, G.A. Andres, M.J. Dunn, Glomerular prostaglandin and thromboxane synthesis in rat nephrotoxic serum nephritis, J. Clin. Invest. 72:1439–1448 (1983).

    PubMed  CAS  Google Scholar 

  43. G. Camussi, C. Tetta, G. Segoloni, R. Coda, A. Vercellone, Localization of neutrophil cationic proteins and loww of anionic charges in glomeruli of patients with systemic lupus erythematosus, Clin. Immun. Immunopathol. 24:299–314 (1982).

    CAS  Google Scholar 

  44. C. Patrono, G. Ciabattoni, G. Remuzzi, E. Gotti, S. Bombardieri, O. Di Munno, G. Tartarelli, G.A. Cinotti, B.M. Simonetti, A. Pierucci: Functional significance of renal prostacyclin and thromboxane A2 production in patients with systemic lupus erythematosus, J. Clin. Invest. 76:1011–1018 (1985).

    PubMed  CAS  Google Scholar 

  45. D.M. Brown, D.J. Klein, A.F. Michael, T.R. Oegema, 35S-glycosaminoglycan and 35S-glycopeptide metabolism by diabetic glomeruli and aorta, Diabetes 31:418–425 (1982).

    PubMed  CAS  Google Scholar 

  46. M.P. Cohen, M.L. Surma, Effects of diabetes on in vivo metabolism of S-labeled glomerular basement membrane, Diabetes 33:8–12 (1984).

    PubMed  CAS  Google Scholar 

  47. M.J. Dunn, Renal prostaglandins, in: “Renal Endocrinology,” M.J. Dunn, ed., Williams and Wilkins, Baltimore, pp. 1–74 (1983).

    Google Scholar 

  48. C. Patrono and F. Pugliese, The involvement of arachidonic acid metabolism in the control of renin release, J. Endocrinol. Invest. 3:193–201 (1980).

    PubMed  CAS  Google Scholar 

  49. C. Patrono, Å. Wennmalm, G. Ciabattoni, J. Nowak, F. Pugliese, G.A. Cinotti, Evidence for an extrarenal origin of urinary prostaglandin E2 in healthy men, Prostaglandins 18:623–629 (1979).

    PubMed  CAS  Google Scholar 

  50. M. Hamberg and B. Samuelsson, The structure of the major urinary metabolite of prostaglandin E2 in man, J. Am. Chem. Soc. 91:2177–2178 (1969).

    PubMed  CAS  Google Scholar 

  51. M. Hamberg and B. Samuelsson, On the metabolism of prostaglandin E1 and E2 in man, J. Biol. Chem. 246:6713–6721 (1971).

    PubMed  CAS  Google Scholar 

  52. E. Granström and B. Samuelsson, On the metabolism of PGF2α in female subjects, J. Biol. Chem. 246:5254–5263 (1971).

    PubMed  Google Scholar 

  53. E. Granström and B. Samuelsson, On the metabolism of prostaglandin F2α in female subjects. II. Structures of six metabolites, J. Biol. Chem. 246:7470–7485 (1971).

    PubMed  Google Scholar 

  54. J.C. Frölich, T.W. Wilson, B.J. Sweetman, M. Smigel, A.S. Nies, K. Carr, J.T. Watson, J.A. Oates, Urinary prostaglandins: identification and origin, J. Clin. Invest. 55:763–770 (1975).

    PubMed  Google Scholar 

  55. R.D. Zipser and K. Martin, Urinary excretion of arterial blood prostaglandins and thromboxane in man, Am. J. Physiol. 242:E171–177 (1982).

    PubMed  CAS  Google Scholar 

  56. G.A. FitzGerald, A.K. Pedersen, C. Patrono, Analysis of prostacyclin and thromboxane biosynthesis in cardiovascular disease, Circulation 67:1174–1177 (1983).

    PubMed  CAS  Google Scholar 

  57. F. Pugliese and G. Ciabattoni, Investigations of renal arachidonic acid metabolites by radioimmunoassay, in: “Prostaglandins and The Kidney,” M.J. Dunn, C. Patrono, G.A. Cinotti, eds., Plenum Press, New York, pp. 83–98 (1983).

    Google Scholar 

  58. G. Ciabattoni, F. Pugliese, E. Pinea, G.A. Cinotti, A. De Salvo, M.A. Satta, C. Patrono, Biologic and méthodologie variables affecting urinary prostaglandin measurement, in: “Advances in Prostaglandin, Thromboxane and Leukotriene Research,” B. Samuelsson, P.W. Ramwell, R. Paoletti, eds., Raven Press, New York, Vol. 6, pp. 207–212 (1980).

    Google Scholar 

  59. G. Ciabattoni, F. Pugliese, G.A. Cinotti, C. Patrono, Methodologie problems in the radioimmunoassay of prostaglandin E2 and F2α in human urine, in: “Radioimmunoassay of Drugs and Hormones in Cardiovascular Medicine,” A. Albertini, M. Da Prada, B.A. Peskar, eds., Elsevier/North Holland, Amsterdam, pp. 265–280 (1979).

    Google Scholar 

  60. C. Patrono, F. Pugliese, G. Ciabattoni, P. Patrignani, A. Maseri, S. Chierchia, B.A. Peskar, G.A. Cinotti, B.M. Simonetti, A. Pierucci, Evidence for a direct stimulatory effect of prostacyclin on renin release in man, J. Clin. Invest. 69:231–239 (1982).

    PubMed  CAS  Google Scholar 

  61. C. Patrono, Validation criteria for radioimmunoassay, in: “Radioimmunoassay in Basic and Clinical Pharmacology,” C. Patrono and B.A. Peskar, eds., Handb. Exp. Pharm., Springer-Verlag, Berlin, Vol. 82, pp. 213–225 (1987).

    Google Scholar 

  62. G.A. FitzGerald, A.R. Brash, P.F. Falardeau, J.A. Oates, Estimated rate of prostacyclin secretion into the circulation of normal man, J. Clin. Invest. 68:1272–1276 (1981).

    PubMed  CAS  Google Scholar 

  63. C. Patrono, G. Ciabattoni, F. Pugliese, A. Pierucci, I.A. Blair, G.A. FitzGerald, Estimated rate of thromboxane secretion into the circulation, J. Clin. Invest. 77:590–594 (1986).

    PubMed  CAS  Google Scholar 

  64. J.A. Lawson, C. Patrono, G. Ciabattoni, G.A. FitzGerald, Long-lived enzymatic metabolites of TxB2 in the human circulation, Anal. Biochem. 155:198–205 (1986).

    PubMed  CAS  Google Scholar 

  65. G. Ciabattoni, F. Pugliese, A. Pierucci, B.M. Simonetti, C. Patrono, Fractional conversion of thromboxane B2 to urinary 11-dehydro-thromboxane B2 in man, J. Clin. Invest., submitted for publication.

    Google Scholar 

  66. G. Ciabattoni, J. Maclouf, F. Catella, G.A. FitzGerald, C. Patrono, Radioimmunoassay of 11-dehydro-thromboxane B2 in human plasma and urine, Biochim. Biophys. Acta 918:293–297 (1987).

    PubMed  CAS  Google Scholar 

  67. G. Ciabattoni, F. Pugliese, G.A. Cinotti, G. Stirati, R. Ronci, G. Castrucci, A. Pierucci, C. Patrono, Characterization of furosemide-induced activation of the renal prostaglandin system, Eur. J. Pharmacol. 60:181–187 (1979).

    PubMed  CAS  Google Scholar 

  68. J.R. Gill, Jr., J.C. Frölich, R.E. Bowden, A.A. Taylor, H.R. Keiser, W.S. Hannsjorg, J.A. Oates, F.C. Bartter, Bartter’s syndrome: a disorder characterized by high urinary prostaglandins and a dependence of hyperreninemia on prostaglandin synthesis, Am. J. Med. 61:43–51 (1976).

    PubMed  Google Scholar 

  69. H.G. Güllner, C. Cerletti, F.C. Bartter, J.B. Smith, J.R. Gill, Jr., Prostacyclin overproduction in Bartter’s syndrome, Lancet 11:767–768 (1976).

    Google Scholar 

  70. M.L. Watson, J.R. Gill, R.A. Branch, J.A. Oates, A.R. Brash, Systemic prostaglandin In synthesis is normal in patients with Bartter’s syndrome, Lancet II:368–369 (1983).

    Google Scholar 

  71. L.J. Roberts, B.J. Sweetman, J.A. Oates, Metabolism of thromboxane B2 in man, J. Biol. Chem. 256:8384–8393 (1981).

    PubMed  CAS  Google Scholar 

  72. G. Ciabattoni, G.A. Cinotti, A. Pierucci, B.M. Simonetti, M. Manzi, F. Pugliese, P. Barsotti, G. Pecci, F. Taggi, C. Patrono, Effects of sulindac and ibuprofen in patients with chronic glomerular disease, N. Engl. J. Med. 310:279–283 (1984).

    PubMed  CAS  Google Scholar 

  73. G. Ciabattoni, F. Pugliese, G.A. Cinotti, C. Patrono, Renal effects of anti-inflammatory drugs, Eur. J. Rheumatol. Inflam. 3:210–221 (1980).

    CAS  Google Scholar 

  74. P. Patrignani, P. Filabozzi, C. Patrono, Selective cumulative inhibition of platelet thromboxane production by low-dose aspirin in healthy subjects, J. Clin. Invest. 69:1366–1372 (1982).

    PubMed  CAS  Google Scholar 

  75. F. Catella, F. Pugliese, P. Patrignani, P. Filabozzi, G. Ciabattoni, C. Patrono, Differential platelet and renal effects of sulfinpyrazone in man, (Abstract), Clin. Res. 32:239A (1984).

    Google Scholar 

  76. P. Patrignani, P. Filabozzi, F. Catella, F. Pugliese, C. Patrono, Differential effects of dazoxiben, a selective thromboxane-synthase inhibitor, on platelet and renal prostaglandin-endoperoxide metabolism, J. Pharmacol. Exp. Ther. 228:472–477 (1984).

    PubMed  CAS  Google Scholar 

  77. C. Patrono, G. Ciabattoni, P. Filabozzi, F. Catella, L. Forni, M. Segni, P. Patrignani, F. Pugliese, B.M. Simonetti, A. Pierucci, Drugs, Prostaglandin and Renal Function, in: “Advances in Prostaglandin, Thromboxane and Leukotriene Research,” G.G. Neri Serneri, J.C. McGiff, R. Paoletti, G.N.R. Born, eds., Raven Press, New York, Vol. 3, pp. 131–139 (1985).

    Google Scholar 

  78. P. Patrignani, F. Catella, P. Filabozzi, F. Pugliese, A. Pierucci, B.M. Simonetti, L. Forni, M. Segni, C. Patrono, Differential effects of OKY-046, a selective thromboxane-synthase inhibitor, on platelet and renal prostaglandin endoperoxide metabolism, (Abstract), Clin. Res. 32:246A (1984).

    Google Scholar 

  79. G.J. Roth, N.S. Stanford, P.W. Majerus, Acetylation of prostaglandin synthase by aspirin, Proc. Natl. Acad. Sci. USA 72:3073–3077 (1975).

    PubMed  CAS  Google Scholar 

  80. F.J. Van der Ouderaa, M. Buytenhek, D.H. Nugteren, D.A. Van Dorp, Acetylation of prostaglandin endoperoxide synthase with acetylsalicylic acid, Eur. J. Biochem. 109:1–8 (1980).

    Google Scholar 

  81. C. Patrono, G. Ciabattoni, P. Patrignani, P. Filabozzi, E. Pinca, M.A. Satta, D. Van Dorne, G.A. Cinotti, F. Pugliese, A. Pierucci, B.M. Simonetti, Evidence for a renal origin of urinary TxB2 in health and disease, in: “Advances in Prostaglandin, Thromboxane and Leukotriene Research,” B. Samuelsson, R. Paoletti, P. Ramwell, eds., Raven Press, New York, Vol. 11, pp. 493–498 (1983).

    Google Scholar 

  82. G.A. FitzGerald, J.A. Oates, J. Hawiger, R.L. Maas, L.J. Roberts II, J.A. Lawson, A.R. Brash, Endogenous biosynthesis of prostacyclin and thromboxane and platelet function during chronic administration of aspirin in man, J. Clin. Invest. 71:676–688 (1983).

    PubMed  CAS  Google Scholar 

  83. G. Ciabattoni, A.H. Boss, L. Daffonchio, J. Daugherty, G.A. FitzGerald, F. Catella, F. Dray, C. Patrono, Radioimmunoassay measurement of 2,3-dinor metabolites of prostacyclin and thromboxane in human urine, in: “Advances in Prostaglandin, Thromboxane and Leukotriene Research,” B. Samuelsson, R. Paoletti, P.W. Ramwell, eds., Raven Press, New York, Vol. 17, pp. 598–602 (1987).

    Google Scholar 

  84. C. Patrono, G. Ciabattoni, E. Pinca, F. Pugliese, G. Castrucci, A. De Salvo, M.A. Satta, B.A. Peskar, Low-dose aspirin and inhibition of thromboxane B2 production in healthy subjects, Thromb. Res. 17:317–327 (1980).

    PubMed  CAS  Google Scholar 

  85. D.E. Duggan, L.E. Hare, C.A. Ditzler, B.W. Lei, C. Kwan, The disposition of sulindac, Clin. Pharmacol. Ther. 21:326–335 (1977).

    PubMed  CAS  Google Scholar 

  86. J.R. Sedor, S.L. Williams, A.N. Chremos, C.L. Johnson, M.J. Dunn, Effects of sulindac and indomethacin on renal prostaglandin synthesis, Clin. Pharmacol. Ther. 36:85–91 (1984).

    PubMed  CAS  Google Scholar 

  87. J.L. Nadler, M. McKay, V. Campese, J. Vrbanac, R. Horton, Evidence that prostacyclin modulates the vascular actions of calcium in man, J. Clin. Invest. 77:1278–1284 (1986).

    PubMed  CAS  Google Scholar 

  88. R. Vriesendorp, D. De Zeeuw, P.E. De Jong, A.J.M. Donker, J.J. Pratt, G.K. van der Hem, Reduction of urinary protein and prostaglandin E2 excretion in the nephrotic syndrome by nonsteroidal anti-inflammatory drugs, Clin. Nephrol. 25:105–110 (1986).

    PubMed  CAS  Google Scholar 

  89. A. Salvetti, R. Pedrinelli, P. Alberici, A. Magagna, B. Abdel-Haq, The influence of indomethacin and sulindac on some pharmacological actions of atenolol in hypertensive patients, Br. J. Clin. Pharmacol. 17:108S-111S (1984).

    PubMed  Google Scholar 

  90. A. Salvetti, R. Pedrinelli, A. Magagna, P. Ugenti, Differential effects of selective and non-selective prostaglandin-synthesis inhibition on the pharmacological responses to Captopril in patients with essential hypertension, Clin. Sci. 63:261S-263S (1982).

    Google Scholar 

  91. I.B. Puddey, L.J. Beilin, R. Vandongen, R. Banks, I. Rouse, Differential effects of sulindac and indomethacin on blood pressure in treated essential hypertensive subjects, Clin. Sci. 69:327–336 (1985).

    PubMed  CAS  Google Scholar 

  92. CD. Mistry, C.J. Lote, R. Gokal, W.J. Currie, M. Vandenburg, M.P. Mallick, Effects of sulindac on renal function and prostaglandin synthesis in patients with moderate chronic renal insufficiency, Clin. Sci. 70:501–505 (1986).

    PubMed  CAS  Google Scholar 

  93. F. Guarner, C. Guarner, J. Prieto, I. Colina, J. Quiroga, J. Casas, R. Freixa, J. Posello, E. Gelpi, J. Balanzo, Increased synthesis of systemic prostacyclin in cirrhotic patients, Gastroenterology 90:687–694 (1986).

    PubMed  CAS  Google Scholar 

  94. G. Laffi, G. La Villa, M. Pinzani, G. Ciabattoni, P. Patrignani, M. Mannelli, F. Cominelli, P. Gentilini, Altered renal and platelet arachidonic acid metabolism in cirrhosis, Gastroenterology 90:274–282 (1986).

    PubMed  CAS  Google Scholar 

  95. U.G. Svendsen, J. Gerstoft, T.M. Hansen, P. Christensen, I.B. Lorenzen, The renal excretion of prostaglandins and changes in plasma renin during treatment with either sulindac or naproxen in patients with rheumatoid arthritis and thiazide-treated heart failure, J. Rheumatol. 11:779–782 (1984).

    PubMed  CAS  Google Scholar 

  96. D.C. Brater, S. Anderson, B. Baird, W.B. Campbell, Effects of ibuprofen, naproxen and sulindac on prostaglandins in men, Kidney Int. 27: 66–73 (1985).

    PubMed  CAS  Google Scholar 

  97. D.G. Roberts, J.G. Gerber, J.S. Barnes, G.O. Zerbe, A.S. Nies, Sulindac is not renal-sparing in man, Clin. Pharmacol. Ther. 38:258–265 (1985).

    PubMed  CAS  Google Scholar 

  98. K.J. Berg and T. Talseth, Acute effects of sulindac and indomethacin in chronic renal failure, Clin. Pharmacol. Ther. 37:447–452 (1985).

    PubMed  CAS  Google Scholar 

  99. G. Laffi, G. Daskalopoulos, I. Kronborg, W. Hsueh, P. Gentilini, R.D. Zipser, Effects of sulindac and ibuprofen in patients with cirrhosis and ascites. An explanation for the renal-sparing effect of sulindac, Gastroenterology 90:182–187 (1986).

    PubMed  CAS  Google Scholar 

  100. E. Quintero, P. Gines, V. Arroyo, A. Rimola, J. Camps, J. Gaya, A. Guevara, M. Rodamilans, J. Rodes, Sulindac reduces the urinary excretion of prostaglandins and impairs renal function in cirrhosis with ascites, Nephron 42:298–303 (1986).

    PubMed  CAS  Google Scholar 

  101. C. Patrono and M.J. Dunn, The clinical significance of inhibition of renal prostaglandin synthesis, Kidney Int. 32:1–12 (1987).

    PubMed  CAS  Google Scholar 

  102. G. Ciabattoni, A.H. Boss, P. Patrignani, F. Catella, B.M. Simonetti, A. Pierucci, F. Pugliese, P. Filabozzi, C. Patrono, Effects of sulindac on renal and extrarenal eicosanoid synthesis, Clin. Pharmaco1. Ther. 41:380–383 (1987).

    CAS  Google Scholar 

  103. A. Kirstein Pedersen and P. Jakobsen, Sulfinpyrazone metabolism during long-term therapy, Br. J. Clin. Pharmacol. 11:597–603 (1981).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacology, Catholic University School of Medicine, Rome, Italy

    Giovanni Ciabattoni & Francesco Pugliese

  2. II Clinica Medica, Cattedra di Nefrologia Rome University “La Sapienza,”, Rome, Italy

    Giovanni Ciabattoni & Francesco Pugliese

Authors
  1. Giovanni Ciabattoni
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Francesco Pugliese
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Case Western Reserve University, Cleveland, Ohio, USA

    Michael J. Dunn

  2. University Hospitals of Cleveland, Cleveland, Ohio, USA

    Michael J. Dunn

  3. Catholic University School of Medicine, Rome, Italy

    Carlo Patrono

  4. University of Rome “La Sapienza”, Rome, Italy

    Giulio A. Cinotti

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Plenum Press, New York

About this chapter

Cite this chapter

Ciabattoni, G., Pugliese, F. (1989). Studies of Renal Eicosanoid Synthesis In Vivo and In Vitro. In: Dunn, M.J., Patrono, C., Cinotti, G.A. (eds) Renal Eicosanoids. Advances in Experimental Medicine and Biology, vol 259. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5700-1_15

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-5700-1_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5702-5

  • Online ISBN: 978-1-4684-5700-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation