The Molecular, Biochemical and Human Pharmacology of Thromboxane A2 in Renal Disease

  • Garret A. FitzGerald
  • Rosemary Murray
  • Patricia Price
  • Francesca Catella
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 259)


Arachidonic acid is a constituent of the phospholipid domain of biological membranes. Activation of phospholipases results in its release into the intracellular milieu where it is subject to metabolism to biologically active compounds. In most cell types, including the platelet (1), the predominant enzyme involved in catalyzing arachidonate release is phospholipase A2 rather than phospholipase C (2). It has recently been shown that arachidonate may be subject to direct oxygenation within the cell membrane (3); the biological role of this process remains speculative.


Renal Blood Flow Human Platelet Thrombotic Thrombocytopenic Purpura Thromboxane Synthesis Thromboxane Production 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Garret A. FitzGerald
    • 1
  • Rosemary Murray
    • 1
  • Patricia Price
    • 1
  • Francesca Catella
    • 1
  1. 1.Division of Clinical PharmacologyVanderbilt UniversityNashvilleUSA

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