Cytoprotective Therapy Prostaglandins

  • Donald E. Wilson


Prostaglandins are 20-carbon cyclic fatty acids synthesized from dietary fatty acids by virtually all mammalian cells. These naturally occurring compounds are biologically active, affect most cellular functions, and have both physiologic and pharmacologic effects in animals and in humans. Prostaglandins (PG) represent one of two known groups of arachidonic acid metabolites, collectively known as eicosanoids (Fig. 1). Because of their gastric acid antisecretory effects, as well as their ability to enhance gastroduodenal mucosal integrity, PG have undergone extensive evaluation in animals and in human subjects as potential antiulcer drugs. Naturally occurring PG are rapidly metabolized by enzyme systems present in most tissues, particularly in the lungs, liver, and gastrointestinal (GI) tract, so that their actions are short-lived, unless they are administered by constant infusion in relatively high concentrations. A number of metabolically stable PG analogues have been synthesized that are not only more potent than their natural counterparts but are also active by the oral route. This chapter reviews some of the data supporting a physiologic and therapeutic role for PG in maintaining mucosal integrity.


Duodenal Ulcer Peptic Ulcer Disease Gastric Mucosal Injury Mucosal Integrity Duodenal Ulcer Patient 
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Annotated Bibliography

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Copyright information

© Plenum Publishing Corporation 1989

Authors and Affiliations

  • Donald E. Wilson
    • 1
  1. 1.Department of MedicineState University of New York, Health Science Center at BrooklynBrooklynUSA

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