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Cytoprotective Therapy Prostaglandins

  • Donald E. Wilson

Abstract

Prostaglandins are 20-carbon cyclic fatty acids synthesized from dietary fatty acids by virtually all mammalian cells. These naturally occurring compounds are biologically active, affect most cellular functions, and have both physiologic and pharmacologic effects in animals and in humans. Prostaglandins (PG) represent one of two known groups of arachidonic acid metabolites, collectively known as eicosanoids (Fig. 1). Because of their gastric acid antisecretory effects, as well as their ability to enhance gastroduodenal mucosal integrity, PG have undergone extensive evaluation in animals and in human subjects as potential antiulcer drugs. Naturally occurring PG are rapidly metabolized by enzyme systems present in most tissues, particularly in the lungs, liver, and gastrointestinal (GI) tract, so that their actions are short-lived, unless they are administered by constant infusion in relatively high concentrations. A number of metabolically stable PG analogues have been synthesized that are not only more potent than their natural counterparts but are also active by the oral route. This chapter reviews some of the data supporting a physiologic and therapeutic role for PG in maintaining mucosal integrity.

Keywords

Duodenal Ulcer Peptic Ulcer Disease Gastric Mucosal Injury Mucosal Integrity Duodenal Ulcer Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Annotated Bibliography

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Copyright information

© Plenum Publishing Corporation 1989

Authors and Affiliations

  • Donald E. Wilson
    • 1
  1. 1.Department of MedicineState University of New York, Health Science Center at BrooklynBrooklynUSA

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