Epithelial Cell Renewal

  • Gregory L. Eastwood


The epithelium of the gastrointestinal (GI) tract undergoes constant rapid renewal. This process is an important mechanism of mucosal protection throughout the GI tract because it maintains the functional integrity of the epithelium and is also necessary for the repair of mucosal injury. Thus, it is reasonable to expect that certain conditions and agents that predispose to peptic ulcer disease or mucosal injury may do so in part by affecting epithelial renewal in the upper GI tract.


Mucosal Injury Chronic Gastritis Gastric Inhibitory Polypeptide Epithelial Proliferation Proliferative Zone 
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Annotated Bibliography

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  2. Eastwood GL: Gastrointestinal epithelial renewal. Gastroenterology 72:962–975, 1977. General review of gastrointestinal epithelial renewal.PubMedGoogle Scholar
  3. Eastwood GL, Kuwayama H: Effects of ulcerogens and other conditions on gastric epithelial proliferation, in Szabo S, Pfeiffer C(eds): Ulcer Disease: New Aspects of Pathogenesis and Pharmacology. Boca Raton, FL, CRC Press, 1989. Details of the studies of the effects of aspirin, indomethacin, alcohol, histamine-2 antagonists, steroids, and water immersion restraint stress on epithelial proliferation.Google Scholar
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Copyright information

© Plenum Publishing Corporation 1989

Authors and Affiliations

  • Gregory L. Eastwood
    • 1
  1. 1.Gastroenterology DivisionUniversity of Massachusetts Medical SchoolWorcesterUSA

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