Pathomorphology of Gastric Mucosal Injury
Normal gastric mucosa shows regional differences. There are five regions: cardia, fundus, body (corpus), antrum, and pylorus (Fig. 1). The cardia that occupies a relatively small area at the esophagogastric junction contains mucoid glands with some acinar arrangement. The mucosa of the fundic area and body (corpus) of the stomach consists of oxyntic glands draining into gastric pits (Fig. 2). Oxyntic glands consist of parietal cells secreting acid and intrinsic factor, chief cells producing pepsinogens, and endocrine cells. The most common endocrine cells in oxyntic mucosa are enterochromaffrin-like (ECI) cells and A (X) cells. Their hormonal products remain unknown. The antrum extends from the body of the stomach to the pylorus. The gastric mucosa in this region gradually (through the intermediate zone) converts into an antral type with mucoid glands containing mucus and endocrine cells, especially gastrin-produc-ing G cells. The pylorus is the sphincteric orifice opening into the duodenum.
KeywordsGastric Mucosa Parietal Cell Gastric Gland Chief Cell Surface Epithelial Cell
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