Gastroprotection by Nonprostaglandin Substances

  • Stanislaw J. Konturek
  • Jan W. Konturek


Cytoprotection is the term originally introduced into gastrointestinal (GI) pa-thophysiology by Robert to describe the unique feature of prostaglandins (PG) to prevent acute necrotic lesions of the GI mucosa at nonantisecretory doses. This phenomenon has been studied extensively, primarily in experimental animals, and two major categories of cytoprotection have been identified: direct cytoprotection induced by PG administered exogenously, and adaptive cytoprotection elicited by mild irritants and probably mediated by endogenous PG. Since histologic examination of the PG-protected mucosa reveals that only deep hem-orrhagic necrosis is prevented — the surface epithelium becomes damaged — the term cytoprotection has been questioned. Although the surface epithelium cells are lost, the prevention by PG of deep hemorrhagic necrosis and of damage to the cells around the mucous neck allows for rapid cell migration and restitution of the integrity of surface epithelium and almost complete preservation of organ functions. The use of organoprotection (e. g., gastroprotection) is now recommended and is reviewed in this chapter.


Epidermal Growth Factor Gastric Mucosa Gastric Mucosal Injury Gastroprotective Effect Colloidal Bismuth Subcitrate 
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Annotated Bibliography

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Copyright information

© Plenum Publishing Corporation 1989

Authors and Affiliations

  • Stanislaw J. Konturek
    • 1
  • Jan W. Konturek
    • 1
  1. 1.Institute of PhysiologyAcademy of MedicineKrakowPoland

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