Cytoprotection Historical Perspective
Traditionally, the aim of antiulcer therapy has been either to inhibit secretion of gastric acid by parietal cells or neutralize acid that has already been secreted. To this effect, the use of antacids has been, and continues to be, an effective form of treatment, especially for duodenal ulcer. Anticholinergic agents, by inhibiting the action of acetylcholine (ACh), had been used until the mid-1970s, although the occurrence of side effects always prevented administration of adequate doses. The advent of histamine H2-antagonists, first metiamide, and later cimetidine, ranitidine, and famotidine, led to the administration of strongly antisecretory doses with only minimal side effects and accelerated the healing of peptic ulcer. More recently, omeprazole, a substituted benzimidazole that inhibits (H+-K+)-ATPase within the parietal cell canaliculi, was shown to inhibit acid secretion totally and to induce duodenal ulcer healing in 2 weeks.
KeywordsGastric Mucosa Acid Secretion Intestinal Lesion Gastric Mucosal Injury Gastric Mucosal Cell
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