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Disorders of Intestinal Motility Resulting from Drug Therapy

  • M. A. K. Khalil
  • W. G. Thompson
Part of the Topics in Gastroenterology book series (TGEN)

Abstract

The approach to a patient with gastrointestinal symptoms must include a careful drug history. Perusal of drug formularies and pharmacopoeias reveals that few drugs do not have potential gut side effects. Much suffering might be avoided if the constipated patient with low back pain would discontinue codeine, or the diarrhea patient with peptic ulcers cease magnesium-containing antacids. Such undesirable effects are so ubiquitous that, on principle, any drug the gut complainant takes should be suspect.

Keywords

Irritable Bowel Syndrome Gastric Emptying Lower Esophageal Sphincter Gastrointestinal Motility Migrate Motor Complex 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Thompson WG: Laxatives: Clinical pharmacology and rational use. Drugs 19: 49–58, 1980PubMedCrossRefGoogle Scholar
  2. 2.
    Burks TF: Actions of drugs on gastrointestinal motility, in Johnson LR (ed): Physiology of the gastrointestinal tract, ed 2. New York, Raven Press, 1987, pp 723–743Google Scholar
  3. 3.
    Farrar JT: The effects of drugs on intestinal motility. Clin Gastroenterol 11 (3): 673–681, 1982PubMedGoogle Scholar
  4. 4.
    Connell AM: Colonic motility in megacolon. Proc R Soc Med 54: 1040–1043, 1961Google Scholar
  5. 5.
    Morris AI, Turnberg LA: The influences of a parasympathetic agonist and antagonist on human intestinal transport in vivo. Gastroenterology 79: 861–866, 1980PubMedGoogle Scholar
  6. 6.
    Christensen J: Motility of the colon, in Johnson LR (ed): Physology of the Gastrointestinal Tract, ed 2. New York, Raven Press, 1987, pp 665–692Google Scholar
  7. 7.
    Sun EA, Snape WJ, Cohen S, et al: The role of opiate receptors and cholinergic neurons in the gastrocolonic response. Gastroenterology 82: 689–693, 1982PubMedGoogle Scholar
  8. 8.
    Warnes H, Lehman HE: Adynamic ileus during psychoactive medication: A report of three fatal and five severe cases. Can Med Assoc J 96: 1112–1113, 1967PubMedGoogle Scholar
  9. 9.
    Giordano J, Huang A, Canter JW: Fatal paralytic ileus complicating phenothiazine therapy. South Med J 68 (13): 351–353, 1975PubMedCrossRefGoogle Scholar
  10. 10.
    Milner G, Hill NF: Adynamie ileus and nortriptyline. Br Med J 1: 841–842, 1966PubMedCrossRefGoogle Scholar
  11. 11.
    Ivey KJ: Are anticholinergics of use in the irritable colon syndrome? Gastroenterology 68: 1300–1307, 1975PubMedGoogle Scholar
  12. 12.
    Jay BH, Abrahamsson H, Stockbruegger RW, et al: Effect of selective and non-selective antimuscarinics on rectosigmoid motility and gastrointestinal transit. Scand J Gastroenterol 20: 1101–1109, 1985CrossRefGoogle Scholar
  13. 13.
    Lederer PC, Thiemann R, Femppel J, et al: Influence of atropine, pirenzepine and cimetidine on nocturnal gastrointestinal motility and gastric acid secretion. Scand J Gastroenterol 17 (suppl 72): 131–137, 1982Google Scholar
  14. 14.
    Kleist OV, Janisch HD, Bauer FE: Proceedings of the XII International Congress of Gastroenterology, Lisbon, 1984 (abstr)Google Scholar
  15. 15.
    Hoffman BB: Adrenergic receptor-activating drugs, in Katzung BG (ed): Basic and Clinical Pharmacology, ed 2. Lange Medical Publications, Los Altos, Calif, 1984, pp 86–106Google Scholar
  16. 16.
    Bucknel A, Whitney B: A preliminary investigation of the pharmacology of the human isolated toenia coli prep. Br J Pharmacol 23: 164–175, 1964Google Scholar
  17. 17.
    Glise H, Hallerback B: Effects of propranolol on post-op ileus after colonic surgery. Gastroenterology 84: 1169, 1983Google Scholar
  18. 18.
    Altaparmakov IA, Erckenbrecht JF, Wienbeck M: Modulation of adrenergic system in the treatment of post-op bowel atonia. Scand J Gastroenterol 1104–1106, 1984Google Scholar
  19. 19.
    Weiner N: Drugs that inhibit adrenergic nerves and block adrenergic receptors, in Gilman AG, Goodman LS, Rall TW (eds): The Pharmacological Basis of Therapeutics, ed 7. New York, Macmillan Co, 1985, p 203Google Scholar
  20. 20.
    Jaffe, JH: Drug addiction and drug abuse, in Gilman AG, Goodman LS, Rall TW (eds): The Pharmacological Basis of Therapeutics, ed 7. New York, Macmillan Co, 1985, p 569Google Scholar
  21. 21.
    Thorpe JAC: Effect of propranolol on lower esophageal sphincter in man. Curr Med Res Opinion 7: 91–95, 1980CrossRefGoogle Scholar
  22. 22.
    Lyrenas E: Beta adrenergic influence on esophageal and colonic motility in man. Scand J Gastroenterol Suppl 116: 1–48, 1985PubMedCrossRefGoogle Scholar
  23. 23.
    Abrahamsson H, Dotevall G: Effects of propranolol on colonic pressure in patients with irritable bowel syndrome. Scand J Gastroenterol 16: 1021–1024, 1981PubMedCrossRefGoogle Scholar
  24. 24.
    Zacharias FJ: Patient acceptability of propranolol and the occurrence of side effects. Postgrad Med J 52 (suppl 4): 87–89, 1976PubMedGoogle Scholar
  25. 25.
    Greenblatt DJ, Koch-Weser J: Adverse reactions to β-adrenergic rceptor blocking drugs: A report from the Boston collaborative drug surveillance program. Drugs 7: 118–129, 1974PubMedCrossRefGoogle Scholar
  26. 26.
    VanNueten JM, Schuurkes JAJ: Studies on the role of dopamine and dopamine blockers in gastroduodenal motility. Scand J Gastroenterol Suppl 96: 90–99, 1984Google Scholar
  27. 27.
    Schuurkes JAJ, VanNueten JM: Is dopamine an inhibitory modulator of gastrointestinal motility? Scand J Gastroenterol 16 (suppl 67): 33–36, 1981Google Scholar
  28. 28.
    Horowitz M, Harding PE, Chatterton BE, et al: Acute and chronic effects of domperidone on gastric emptying in diabetic autonomic neuropathy. Dig Dis Sci 30 (1): 1–9, 1985PubMedCrossRefGoogle Scholar
  29. 29.
    Schade RR, Dugas MC, Lhotsky DM, et al: Effect of metoclopramide on gastric liquid emptying in patients with diabetic gastroparesis. Dig Dis Sci 30 (1): 10–15, 1985PubMedCrossRefGoogle Scholar
  30. 30.
    Bianchine JR: Drugs for Parkinson’s disease, spasticity and acute muscle spasm, in Gilman AG, Goodman LS, Rall TW (eds): The Pharmacological Basis of Therapeutics, ed 7. New York, Macmillan Co, 1985. pp 473–490Google Scholar
  31. 31.
    Schindler JS, Finnerty GI. Towlson K, et al: Domperidone and levodopa in Parkinson’s disease. Br I Clin Pharmacol 18:959–962, 1984Google Scholar
  32. 32.
    Quinn N, Illas A, Lhermitte F, et al: Bromocriptine and domperidone in the treatment of Parkinson’s disease. Neurology 31: 662–667, 1981PubMedGoogle Scholar
  33. 33.
    LanFranchi GA, Marzio L, Cortini C, et al: Motor effect of dopamine on human sigmoid colon. Am J Dig Dis 23 (3): 257–263, 1978PubMedCrossRefGoogle Scholar
  34. 34.
    Wiley J, Owyang C: Dopaminergic modulation of rectosigmoid motility: Action of domperidone. Pharmacol Exp Ther 242 (2): 548–551, 1987Google Scholar
  35. 35.
    LanFranchi GA, Bazzocchi G, Fois F, et al: Effect of domperidone and dopamine on colonic motor activity in patients with irritable bowel syndrome. Eur J Clin Pharmacol 29: 307–310, 1985PubMedCrossRefGoogle Scholar
  36. 36.
    Cann PA, Read NW, Holdsworth CD: Oral domperidone: Double blind comparison with placebo in IBS. Gut 24: 1135–1140, 1983PubMedCrossRefGoogle Scholar
  37. 37.
    Fielding JF: Domperidone treatment in IBS. Digestion 23: 125–127, 1982PubMedCrossRefGoogle Scholar
  38. 38.
    Shea-Donahue PT, Adams N, Arnold J, et al: Effects of met-enkephalin and naloxone on gastric emptying and secretion in rhesus monkeys. Am J Physiol 245: G196–G200, 1983Google Scholar
  39. 39.
    Coelho JCU, Runkel N, Herfarth C, et al: Effect of analgesic drugs on electromyographic activity of the gastrointestinal tract and sphincter of Oddi and on biliary pressure. Ann Surg 204 (1): 53–58, 1984CrossRefGoogle Scholar
  40. 40.
    Wingate DL, Malagelada JR, Read NW, et al: General discussion—phase activity. Scan J Gastroenterol Suppl 96: 157–158, 1984Google Scholar
  41. 41.
    Jaffe JH, Martin WR: Opioid analgesics and antagonists, in Gilman AG, Goodman LS, Ra11 TW (eds): The Pharmacological Basis of Therapeutics, ed 7. New York, Macmillan Co, pp 491–531, 1985Google Scholar
  42. 42.
    Diamant N: Enkephalinergic control of gastrointestinal motility: From “gut brain” to trimebutine. Can J Gastroenterol 1 (1): 41–43, 1987Google Scholar
  43. 43.
    Kreek MJ, Shaefer RA, Elliot FH: Naloxone, a specific opioid antagonist, reverses chronic idiopathic constipation. Lancet 1: 261–262, 1983PubMedCrossRefGoogle Scholar
  44. 44.
    Kachur JF, Miller RJ, Field M: Control of guinea pig intestinal electrolyte secretion by delta receptors. Proc Natl Acad Sci USA 77: 2753–2756, 1980PubMedCrossRefGoogle Scholar
  45. 45.
    Manara L, Bianchetti A: The central and peripheral influences of opioids on gastrointestinal propulsion. Annu Rev Pharmacol Toxicol 25: 249–273, 1985PubMedCrossRefGoogle Scholar
  46. 46.
    Barone FC, White RF, Ormsbee HS, et al: Effects of calcium channel entry blockers, nifedipine and nilvadipine on colonic motor activity. Pharmacol Exp Ther 237 (1): 99–106, 1986Google Scholar
  47. 47.
    Reynolds IJ, Gould RJ, Snyder HS: Loperamide: Blockade of calcium channels as a mechanism for antidiarrheal effect. Pharmacol Exp Ther 231: 628–632, 1984Google Scholar
  48. 48.
    Ward DJ, Ward JW, Griffo W, et al: Intravenous Cat+ for fecal impaction secondary to verapamil. N Engl J Med 307 (27): 1709, 1982PubMedGoogle Scholar
  49. 49.
    Traube M, Lange RC, McAllister RG, et al: Effect of nifedipine on gastric emptying in normal subjects. Dig Dis Sci 30 (8): 710–712, 1985PubMedCrossRefGoogle Scholar
  50. 50.
    Narducci F, Bassotti G, Gaburri M, et al: Nifedipine reduces the colonic motor response to eating in patients with the irritable colon syndrome. Am J Gastroenterol 80 (5): 317–319, 1985PubMedGoogle Scholar
  51. 51.
    Prior A, Harris SR, Whorwell PJ: Reduction of colonic motility by intravenous nicardipine in irritable bowel syndrome. Gut 28: 1609–1612, 1987PubMedCrossRefGoogle Scholar
  52. 52.
    Bennett A, Eley KG, Scholes GB: Effect of PGE1 and E2 on human, guinea pig and rat isolated small intestine. Br J Pharmacol 34: 630–638, 1968PubMedGoogle Scholar
  53. 53.
    Bennett A, Eley KG, Stockley A: Inhibition of peristalsis in guinea pig isolated ileum and colon by drugs that block prostaglandin synthesis. Br J Pharmacol 57: 335–340, 1976PubMedGoogle Scholar
  54. 54.
    Thor P, Konturek JW, Konturek SJ: Role of prostaglandins in control of intestinal motility. Am J Physiol 248: G353–G359, 1985PubMedGoogle Scholar
  55. 55.
    Horton EW, Main IHM, Thompson LJ, et al: The effect of orally administered prostaglandin E on gastric secretion and gastrointestinal motility in man. Gut 9: 655–658, 1968Google Scholar
  56. 56.
    Rush RD, Ruwart Mk The role of accelerated colonic transit in prostaglandin induced diarrhea and its inhibition by prostacyclin. Br J Pharmacol 83: 157–159, 1984PubMedGoogle Scholar
  57. 57.
    Bukhave K, Rask-Madsen J: Prostaglandin E in jejunal fluids and its potential diagnostic value for selecting patients with indomethacin sensitive diarrhea. Eur J Clin Invest 11: 191–197, 1981Google Scholar
  58. 58.
    Beubler E, Jaun H: Effect of ricinoleic acid and other laxatives on net water flux and prostaglandin E release by rat colon. J Pharm Pharmacol 31: 681–685, 1979Google Scholar
  59. 59.
    Moncada S, Flower RI, Vane JR: Prostaglandins, prostacyclin, thromboxane A2 and leukotrienes, in Gilman AG, Goodman LS, Rall TW, et al (eds): The Pharmacological Basis of Therapeutics, ed 7. New York, Macmillan Co, 1985, p 667Google Scholar
  60. 60.
    Pittman FE: Antibiotic associated colitis: An update. Adverse Drug Reaction Bull. 75: 268–271, 1979CrossRefGoogle Scholar
  61. 61.
    Shulze-Delrieu K: Pseudomembraneous colitis and the neuromuscular actions of antibiotics. Gastroenterology 85 (5): 1221–1222, 1983Google Scholar
  62. 62.
    Lees GM, Percy WH: Antibiotic associated colitis: An in-vitro investigation of the effects of antibiotics on intestinal motility. Br J Pharmacol 73: 553–557, 1981Google Scholar
  63. 63.
    Itoh Z, Suzuki T, Nakaya M, et al: Gastrointestinal motor stimulating activity of macrolide antibiotics and analysis of their side effects on canine gut. Antimicrob Agents Chemother 26 (6): 863–869, 1984PubMedGoogle Scholar
  64. 64.
    Tomomasa T, Kuroume T, Arai H, et al: Erythromycin induces migrating motor complex in human GI tract. Dig Dis Sci 31 (2): 157–161, 1986PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1989

Authors and Affiliations

  • M. A. K. Khalil
    • 1
  • W. G. Thompson
    • 1
  1. 1.Digestive Diseases Research Group, Division of GastroenterologyUniversity of Ottawa, Ottawa Civic HospitalOttawaCanada

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