Functional Bowel Disturbances in Childhood

  • Paul E. Hyman
Part of the Topics in Gastroenterology book series (TGEN)


Children or their advocates may seek medical attention for a number of functional gastrointestinal disorders. Most functional disorders of childhood are relatively transient, and specific for a particular stage of development. Several are common conditions, frequently managed successfully by practicing pediatricians and only occasionally requiring more extensive evaluations and interventions by the pediatric gastroenterologist. These conditions include infantile colic, chronic nonspecific diarrhea of infancy, and recurrent abdominal pain of childhood. Two other conditions—constipation and gastroesophageal reflux—are found in adults, but require a different diagnostic approach and treatment for children. One functional disorder is serious but rare: chronic intestinal pseudoobstruction. In common, all of the conditions to be discussed (with the possible exception of infantile colic) are considered to be related to disturbances in gastrointestinal motility.


Gastroesophageal Reflux Recurrent Abdominal Pain Migrate Motor Complex Intestinal Pseudoobstruction Infantile Colic 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Apley J, MacKeith R, Meadow R: The Child and His Symptoms. Oxford. Blackwell, 1978Google Scholar
  2. 2.
    Schaefer CE, Millman HL, Levine GF (eds): Therapies for Psychosomatic Disorders in Children. San Francisco, Jossey—Bass, 1979, pp 41–112Google Scholar
  3. 3.
    Paradise JL: Maternal and other factors in the etiology of infantile colic. J Am Med Assoc 197: 123–131, 1966Google Scholar
  4. 4.
    Brazelton TB: Crying in infancy. Pediatrics 29: 579–588, 1962PubMedGoogle Scholar
  5. 5.
    Clark RL, Ganis FM, Bradford WL: A study of the possible relationship of progesterone to colic. Pediatrics 31: 65–71, 1963Google Scholar
  6. 6.
    Lothe L, Ivarsson SA, Lindberg T: Motilin, vasoactive intestinal polypeptide and gastrin in infantile colic. Acta Paediatr Scand 76: 316–320, 1987PubMedGoogle Scholar
  7. 7.
    Lothe L, Lindberg T, Jakobsson I: Cow’s milk formula as a cause of infantile colic: A double-blind study. Pediatrics 70: 7–10, 1982PubMedGoogle Scholar
  8. 8.
    Jakobsson I. Lindberg T: Cow’s milk proteins cause infantile colic in breast-fed infants: A double-blind crossover study. Pediatrics 71: 268–271, 1983PubMedGoogle Scholar
  9. 9.
    Harris MJ, Petts V, Penny R: Cow’s milk allergy as a cause of infantile colic: Immunofluorescent studies of jejunal mucosa. Aust Paediatr J 13: 276–280, 1977PubMedGoogle Scholar
  10. 10.
    Thomas DW, McGilligan K, Eisenberg LD, et al: Infantile colic and type of milk feeding. Am J Dis Child 141: 451–453, 1987PubMedGoogle Scholar
  11. 11.
    Hwang CP, Danielsson B: Dicyclomine hydrochloride in infantile colic. Br Med J 291: 1014, 1985Google Scholar
  12. 12.
    O’Donovan JC, Bradstock AS: The failure of conventional drug therapy in the management of infantile colic. Am J Dis Child 133: 999–1001, 1979PubMedGoogle Scholar
  13. 13.
    Danielsson B, Hwang CP: Treatment of infantile colic with surface active substance (simethicone). Acta Paediatr Scand 74: 446–450, 1985PubMedGoogle Scholar
  14. 14.
    Gryboski JD, Thayer WR, Spiro HM: Esophageal motility in infants and children. Pediatrics 31: 382–388, 1963PubMedGoogle Scholar
  15. 15.
    Boix-Ochoa J, Canals J: Maturation of the lower esophagus. J Pediatr Surg 11: 749–752, 1979Google Scholar
  16. 16.
    Werlin S, Dodds W, Hogan W, et al: Mechanisms of gastroesophageal reflux in children. J Pediatr 97: 244–249, 1980PubMedGoogle Scholar
  17. 17.
    Hillimeier AC, Lange R, Seashore J, et al: Delayed gastric emptying in infants with gastroesophageal reflux. J Pediatr 98: 190–194, 1981Google Scholar
  18. 18.
    Hillimeier AC, Grill RB, McCallum R, et al: Esophageal and gastric motor abnormalities in gastroesophageal reflux during infancy. Gastroenterology 84: 741–746, 1983Google Scholar
  19. 19.
    Herbst J, Book LS, Johnson P, et al: The lower esophageal sphincter in gastroesophageal reflux. J Clin Gastroenterol 1: 119–123, 1979PubMedGoogle Scholar
  20. 20.
    Menon AP, Schefft GL, Thach BT: Apnea associated with regurgitation in infants. J Pediatr 106: 625–629, 1985PubMedGoogle Scholar
  21. 21.
    Berquist W, Rachelefsky G, Kadden M, et al: Gastroesophageal reflux, associated recurrent pneumonia, and chronic asthma in children. Pediatrics 68: 29–34, 1981PubMedGoogle Scholar
  22. 22.
    Walsh JK, Farrell MK, Keenan WJ: Gastroesophageal reflux in infants: Relation to apnea. J Pediatr 99: 197–199, 1981PubMedGoogle Scholar
  23. 23.
    Berquist WE, Ament ME: Upper GI function in sleeping infants. Am Rev Respir Dis 131 (suppl.): 26–29, 1985Google Scholar
  24. 24.
    Herbst JJ, Book LS, Minton SD: Gastroesophageal reflux causing respiratory distress and apnea in newborn infants. J Pediatr 95: 763–769, 1979PubMedGoogle Scholar
  25. 25.
    Herbst J, Book LS, Bray P: Gastroesophageal reflux in the “near miss” sudden infant death syndrome. J Pediatr 92: 73–75, 1978PubMedGoogle Scholar
  26. 26.
    Cadman D, Richards J, Feldman W: Gastroesophageal reflux in severely retarded children. Dev Med Child Neurol 20: 95–97, 1978PubMedGoogle Scholar
  27. 27.
    Sondheimer JM, Morris BA: Gastroesophageal reflux among severely retarded children. J Pediatr 94: 710–714, 1979PubMedGoogle Scholar
  28. 28.
    Euler AR, Ament ME: Value of esophageal manometric studies in the gastroesophageal reflux of infancy. Pediatrics 59: 58–60, 1977PubMedGoogle Scholar
  29. 29.
    Hyams JS, Ricci A, Litchner AM: Clinical and laboratory correlates of esophagitis in young children. J Pediatr Gastroenterol Nutr 7: 52–56, 1988PubMedGoogle Scholar
  30. 30.
    Cucchiara S, Staiano A, DiLorenzo C, et al: Esophageal motor abnormalities in children with gastroesophageal reflux and peptic esophagitis. J Pediatr 108: 907–910, 1986PubMedGoogle Scholar
  31. 31.
    Biller JA, Winter HS, Grand RJ, et al: Are endoscopie changes predictive of histologic esophagitis in children? J Pediatr 103: 215–218, 1985Google Scholar
  32. 32.
    Dahms BB, Rothstein FC: Barrett’s esophagus in children: A consequence of chronic gastroesophageal reflux. Gastroenterology 86: 318–323, 1984PubMedGoogle Scholar
  33. 33.
    Hassall E, Weinstein WM, Ament ME: Barrett’s esophagus in childhood. Gastroenterology 89: 1331 1337, 1984Google Scholar
  34. 34.
    Orenstein SR, Whittington PF: Positioning for prevention of infant gastroesophageal reflux. J Pediatr 103: 534–537, 1983PubMedGoogle Scholar
  35. 35.
    Sutphen JL, Dillard VL: Effect of feeding volume on early postcibal gastroesophageal reflux in infants. J Pediatr Gastroenterol Nutr 7: 185–188, 1988PubMedGoogle Scholar
  36. 36.
    Bailey DJ, Andres JM, Danek GD, et al; Lack of efficacy of thickened feeding as a treatment for gastroesophageal reflux. J Pediatr 110: 187–189, 1987PubMedGoogle Scholar
  37. 37.
    Orenstein SR, Magill HL, Brooks P: Thickening of infant feedings for therapy of gastroesophageal reflux. J Pediatr 110: 181–186, 1987PubMedGoogle Scholar
  38. 38.
    Sondheimer JM, Arnold GL: Early effect of bethanechol on the esophageal motor function of infants with gastroesophageal reflux. J Pediatr Gastroenterol Nutr 5: 47–51, 1986PubMedGoogle Scholar
  39. 39.
    Hyman P, Abrams C, Dubois A: Effect of metoclopramide and bethanechol on gastric emptying in infants. Pediatr Res 19: 1029–1032, 1985PubMedGoogle Scholar
  40. 40.
    Euler AR: Use of bethanechol for the treatment of gastroesophageal reflux. J Pediatr 96: 321–324, 1980PubMedGoogle Scholar
  41. 41.
    Strickland AD, Chang JHT: Results of treatment of gastroesophageal reflux with bethanechol. J Pediatr 103: 311–313, 1983PubMedGoogle Scholar
  42. 42.
    Machida HM, Forbes DA, Gall DG, et al: Metoclopramide in gastroesophageal reflux of infancy. J Pediatr 112: 483–487, 1988PubMedGoogle Scholar
  43. 43.
    Cucchiara S, Staiano A, Capozzi C, et al: Cisapride for gastroesophageal reflux and peptic oesophagitis. Arch Dis Child 62: 454–457, 1987PubMedGoogle Scholar
  44. 44.
    Sutphen JL, Dillard VL, Pipan ME: Antacid and formula effects on gastric acidity in infants with gastro esophageal reflux. Pediatrics 78: 55–57, 1986PubMedGoogle Scholar
  45. 45.
    Cucchiara S, Staiano A, Romaniello G, et al: Antacids and cimetidine treatment for gastroesophageal reflux and peptic esophagitis. Arch Dis Child 59: 842–847, 1984PubMedGoogle Scholar
  46. 46.
    Fonkalsrud EW, Berquist W, Vargas J, et al: Surgical treatment of the gastroesophageal reflux syndrome in infants and children. Am J Surg 154: 11–18, 1987PubMedGoogle Scholar
  47. 47.
    Berquist WE, Rachelefsky GS, Kadden M, et al: Gastroesophageal reflux-associated recurrent pneumonia and chronic asthma in children. Pediatrics 68: 29–35, 1981PubMedGoogle Scholar
  48. 48.
    Giuffre RM, Rubin S, Mitchell I: Antireflux surgery in infants with bronchopulmonary dysplasia. Am J Dis Child 141: 648–651, 1987PubMedGoogle Scholar
  49. 49.
    Hyman PE: Absent postprandial duodenal motility in a child with cystic fibrosis: Correction of the symptoms and manometric abnormality with cisapride. Gastroenterology 90: 1274–1279, 1986PubMedGoogle Scholar
  50. 50.
    Davidson M, Wasserman R: The irritable colon of childhood (chronic nonspecific diarrhea syndrome). J Pediatr 69: 1027–1038, 1966PubMedGoogle Scholar
  51. 51.
    Davidson M, Sleisinger MH, Almy TP, et al: Studies of distal colonic motility in children. II. Propulsive activity in diarrheal states. Pediatrics 17: 820–830, 1956PubMedGoogle Scholar
  52. 52.
    Fenton TR, Harries JT, Milla PJ: Disordered intestinal motility: A rational basis for toddler diarrhea. Gut 24: 897–903, 1983PubMedGoogle Scholar
  53. 53.
    Cohen SA, Hendricks KM, Mathis RK, et al: Chronic nonspecific diarrhea: Dietary relationships. Pediatrics 64: 402–407, 1979PubMedGoogle Scholar
  54. 54.
    Lloyd-Still JD: Chronic diarrhea of childhood and the misuse of elimination diets. J Pediatr 95: 10–14, 1979PubMedGoogle Scholar
  55. 55.
    Hamdi I, Dodge JA: Toddler diarrhea: Observations on the effects of aspirin and loperamide. J Pediatr Gastroenterol Nutr 4: 362–365. 1985PubMedGoogle Scholar
  56. 56.
    Levine MD: Children with encopresis: A descriptive analysis. Pediatrics 56: 412–416, 1975PubMedGoogle Scholar
  57. 57.
    Fleisher DR: Diagnosis and treatment of disorders of defecation in children. Pediatr Ann, November 1976Google Scholar
  58. 58.
    Silverman A, Roy CC: Pediatric Clinical Gastroenterology. St. Louis, Mosby, 1983, pp 398–399Google Scholar
  59. 59.
    Bakwin H, Davidson M: Constipation in twins. Am J Dis Child 121: 179–181, 1971PubMedGoogle Scholar
  60. 60.
    Gottleib SH, Schuster MM: Dermatoglyphic (fingerprint) evidence for a congenital syndrome of early onset constipation and abdominal pain. Gastroenterology 91: 428–432, 1986Google Scholar
  61. 61.
    Loening-Baucke VA, Younoszai MK: Effect of treatment on rectal and sigmoid motility in chronically constipated children. Pediatrics 73: 199–205, 1984PubMedGoogle Scholar
  62. 62.
    Meunier P. Louis D, deBeaujeu MJ: Physiologic investigation of primary chronic constipation in children: Comparison with barium enema study. Gstroenterology 87: 1351–1357, 1984Google Scholar
  63. 63.
    Loening-Baucke VA, Younoszai MK: Abnormal anal sphincter response in chronically constipated children. J Pediatr 100: 213–218, 1982PubMedGoogle Scholar
  64. 64.
    Loening-Baucke VA: Abnormal rectoanal function in children recovered from chronic constipation and encopresis. Gastroenterology 87: 1299–1304, 1984PubMedGoogle Scholar
  65. 65.
    Davidson M, Bauer CH: Studies of distal colonic motility in children. iv. Achalasia of the distal rectal segment despite presence of ganglia in the myenteric plexuses of this area. Pediatrics 21: 746–761, 1958PubMedGoogle Scholar
  66. 66.
    Corazziari E, Cucchiara S, Staiano A, et al: Gastrointestinal transit time, frequency of defecation, and anorectal manometry in healthy and constipated children. J Pediatr 106: 379–382, 1985PubMedGoogle Scholar
  67. 67.
    Meunier P. Marechal JM, deBeaujeu MJ: Rectoanal pressures and rectal sensitivity in chronic childhood constipation. Gastroenterology 77: 330–336, 1979PubMedGoogle Scholar
  68. 68.
    Arhan P, Devroede G, Jehannin B, et al: Idiopathic disorders of fecal continence in children. Pediatrics 71: 774–779, 1983PubMedGoogle Scholar
  69. 69.
    Wald A, Chandra R, Gabel S, et al: Anorectal manometric and continence studies in childhood encopresis. Dig Dis Sci 29: 554–559, 1984Google Scholar
  70. 70.
    Loening-Baucke VA: Sensitivity of the simoid colon and rectum in children treated for chronic constipation. J Pediatric Gastroenterol Nutr 3: 454–459, 1984Google Scholar
  71. 71.
    Loening-Baucke VA: Pelvic floor dysfunction in encopresis. Gastroenterology 88: 1479–1483, 1985Google Scholar
  72. 72.
    Loening-Baucke VA: Factors responsible for persistence of childhood constipation. J Pediatr Gastroenterol Nutr 6: 915–922, 1987PubMedGoogle Scholar
  73. 73.
    Venugopal S, Mancer K, Shandling B: The validity of rectal biopsy in relation to morphology and distribution of ganglion cells. J Pediatr Surg 16: 433–437, 1981PubMedGoogle Scholar
  74. 74.
    Taitz LS, Wales JKH, Urwin OM, et al: Factors associated with outcome in management of defecation disorders. Arch Dis Child 61: 472–477, 1986PubMedGoogle Scholar
  75. 75.
    Wald A. Chondra R, Gabel S, et al: Evaluation of biofeedback in childhood encopresis. J Pediatr Gastroenterol Nutr 6: 554–558, 1987PubMedGoogle Scholar
  76. 76.
    Abrahamian FP, Lloyd-Still JD: Chronic constipation in childhood: A longitudinal study of 186 patients. J Pediatr Gastroenterol Nutr 3: 460–467, 1984PubMedGoogle Scholar
  77. 77.
    Apley J, Naish N: Recurrent abdominal pains: A field survey of 1,000 school children. Arch Dis Child 33: 165–170, 1958PubMedGoogle Scholar
  78. 78.
    Oster J: Recurrent abdominal pain, headache, and limb pains in children and adolescents. Pediatrics 50: 429–436, 1972PubMedGoogle Scholar
  79. 79.
    Pineiro-Carrero VM, Andres JM, Davis RH. et al: Altered gastroduodenal motility in children with recurrent abdominal pain. Gastroenterology 90: 1586, 1986Google Scholar
  80. 80.
    Dinson SB: Transit time related to clinical findings in children with recurrent abdominal pain. Pediatrics 47: 666–668. 1972Google Scholar
  81. 81.
    Kopel FB, Kim IC, Barbero G: Comparison of rectosigmoid motility in normal children, children with RAP. and children with ulcerative colitis. Pediatrics 39: 539–545. 1967PubMedGoogle Scholar
  82. 82.
    Barr RG, Levine MD, Watkins JB: Recurrent abdominal pain of childhood due to lactose intolerance. A prospective study. N Engl J Med 300: 1449–1452. 1979PubMedGoogle Scholar
  83. 83.
    Liebman WM: Recurrent abdominal pain in children: Lactose and sucrose intolerance, a prospective study. Pediatrics 64: 43–45, 1979PubMedGoogle Scholar
  84. 84.
    Lebenthal E, Rossi TM, Nord KS, et al: Recurrent abdominal pain and lactose absorption in children. Pediatrics 67: 828–832, 1981PubMedGoogle Scholar
  85. 85.
    Blumenthal I, Kelleher J, Littlewood JM: Recurrent abdominal pain and lactose intolerance in childhood. Br Med J 282: 2013–2014, 1981Google Scholar
  86. 86.
    Wald A, Chandra R, Fisher SE, et al: Lactose malabsorption in recurrent abdominal pain of childhood. J Pediatr 100: 65–68, 1982PubMedGoogle Scholar
  87. 87.
    Hyams JS: Sorbitol intolerance: An unappreciated cause of functional gastrointestinal complaints. Gastroenterology 84: 30–33, 1983PubMedGoogle Scholar
  88. 88.
    Kneepkens CMF, Bijleveld CMA, Vonk RJ, et al: The daytime breath hydrogen profile in children with abdominal symptoms and diarrhoea. Acta Paediatr Scand 75: 632–638, 1986PubMedGoogle Scholar
  89. 89.
    Silverman A, Roy CC: Pediatric Clinical Gastroenterology. St. Louis, Mosby, 1983, pp 418–430Google Scholar
  90. 90.
    Apley J: The Child with Abdominal Pain. Oxford, Blackwell, 1964Google Scholar
  91. 91.
    Boyle JT: Functional abdominal pain in childhood, in Cohen S, Soloway RD (eds): Functional Disorders of the Gastrointestinal Tract. Edinburgh, Churchill Livingstone, 1987, pp 189–209Google Scholar
  92. 92.
    Feldman W, McGrath P, Hodgson C, et al: The use of dietary fiber in the management of simple, childhood, idiopathic, recurrent abdominal pain. Am J Dis Child 139: 1216–1218, 1985PubMedGoogle Scholar
  93. 93.
    Magni G, Pierri M, Donzelli F: Recurrent abdominal pain in children: A long term follow-up. Eur J Pediatr 146: 72–74, 1987PubMedGoogle Scholar
  94. 94.
    Christensen MF, Mortensen O: Long-term prognosis in children with recurrent abdominal pain. Arch Dis Child 50: 110–114, 1975PubMedGoogle Scholar
  95. 95.
    Stickler GB, Murphy DB: Recurrent abdominal pain. Am J Dis Child 133: 486–490, 1979PubMedGoogle Scholar
  96. 96.
    Apley J, Hale B: Children with recurrent abdominal pain: How do they grow up? Br Med J 3: 7–8, 1973PubMedGoogle Scholar
  97. 97.
    Krishnamurthy S, Schuffler MD: Pathology of neuromusclar disorders of the small intestine and colon. Gastroenterology 93: 610–639, 1987PubMedGoogle Scholar
  98. 98.
    Rack FJ, Crouch WL: Functional intestinal obstruction in the premature newborn infant. J Pediatr 40: 579–583, 1982Google Scholar
  99. 99.
    Maldonado JE, Gregg JA, Green PA, et al: Chronic idiopathic intestinal pseudoobstruction. Am J Med 49: 203–213, 1970PubMedGoogle Scholar
  100. 100.
    Faulk DL, Anuras S, Gardner D: A familial visceral myopathy. Ann Intern Med 89: 600–606, 1987Google Scholar
  101. 101.
    Schuffler MD, Lowe MC, Bill AH: Studies of idiopathic intestinal pseudoobstruction: I. Heredity hollow visceral myopathy: Clinical and pathological studies. Gastroenterology 73: 327–338, 1977PubMedGoogle Scholar
  102. 102.
    Law DH, Eyck EAT: Familial megaduodenum and megacystis. Am J Med 33: 911–921, 1962Google Scholar
  103. 103.
    Berdon WE, Baker DH, Blanc WA, et al: Megacystis-microcolon intestinal hypoperistalsis syndrome: A new cause of intestinal obstruction in the newborn—report of radiologic findings in five newborn girls. Am J Roentgenol 126: 957–964, 1976Google Scholar
  104. 104.
    Vargas JH, Ament ME: Chronic intestinal pseudo-obstruction syndrome (CIPS) in pediatrics—Results of a North American survey. Clin Res 35: 210A, 1987Google Scholar
  105. 105.
    Smith B: The Neuropathology of the Alimentary Tract. London, Edward Arnold, 1972Google Scholar
  106. 106.
    Anuras S, Mitros FA, Soper RT, et al: Chronic intestinal pseudo-obstruction in young children. Gastroenterology 91: 62–70, 1986PubMedGoogle Scholar
  107. 107.
    Byrne W, Cipel L, Euler A, et al: Chronic idiopathic intestinal pseudoobstruction syndrome in children: Clinical characteristics and prognosis. J Pediatr 90: 585–589, 1977PubMedGoogle Scholar
  108. 108.
    Tanner MS, Smith B, Lloyd J: Functional intestinal obstruction due to deficiency of argyrophil neurons in the myenteric plexus. Arch Dis Child 51: 837–841, 1976PubMedGoogle Scholar
  109. 109.
    Wiswell T, Rawlings J, Wilson J, et al: Megacystis-microcolon-intestinal hypoperistalsis syndrome. Pediatrics 63: 805–808, 1979PubMedGoogle Scholar
  110. 110.
    Waterfall WE, Cameron OG, Sarna SH, et al: Disorganized electrical activity in a child with idiopathic intestinal pseudo-obstruction. Gut 22: 77–83, 1981PubMedGoogle Scholar
  111. 111.
    Puri P, Lake BD, Gorman F, et al: Megacystis-microcolon-intestinal hypoperistalsis syndrome: A visceral myopathy. J Pediatr Surg 18: 64–69, 1983PubMedGoogle Scholar
  112. 112.
    Anuras S, Mitros FA, Milano A, et al: A familial visceral myopathy with dilatation of the entire gastrointestinal tract. Gastroenterology 90: 385–390, 1986PubMedGoogle Scholar
  113. 113.
    Tomomasa T, Itoh Z, Koizumi T, et al: Manometric study on the intestinal motility in a case of megacystis-microcolon-intestinal hypoperistalsis syndrome. J Pediatr Gastroenterol Nutr 4: 307–310, 1985PubMedGoogle Scholar
  114. 114.
    Tomomasa L, Itoh Z, Koizumi T, et al: Non-migrating rhythmic activity in the stomach and duodenum of neonates. Biol Neonate 48: 1–9, 1985PubMedGoogle Scholar
  115. 115.
    Tomomasa T, Hyman PE, Itoh K, et al: Gastroduodenal motility in neonates: Response to human milk compared to cow milk formula. Pediatrics 80: 434–438, 1987.PubMedGoogle Scholar
  116. 116.
    VanTrappen G, Janssens J, Hellemans J: The interdigestive motor complex of normal subjects and patients with bacterial overgrowth of the small intestine. J Clin Invest 59: 1158–1166, 1977PubMedGoogle Scholar
  117. 117.
    Hyman PE, McDiarmid SV, Napolitano JA, et al: Antroduodenal motility in children with chronic intestinal pseudo-obstruction. J Pediatr 112: 899–905, 1988PubMedGoogle Scholar
  118. 118.
    Boige N, Cargill G, Mashako L, et al: Trimebutine induced phase Ill-like activity in infants with intestinal motility disorders. J Pediatr Gastroenterol Nutr 6: 548–553, 1987PubMedGoogle Scholar
  119. 119.
    Telander RL, Morgan KG, Kreolen DL, et al: Human gastric atony with tachygastria and gastric retention. Gastroenterology 75: 497–501, 1978PubMedGoogle Scholar
  120. 120.
    Cucchiara S, Janssens J, VanTrappen G, et al: Gastric electrical dysrhythmias (tachygastria and tachyarrhythmia) in a girl with chronic intractable vomiting. J. Pediatr. 108: 264–267, 1986PubMedGoogle Scholar
  121. 121.
    Camilleri M, Brown ML, Malagelada JR: Impaired transit of chyme in chronic intestinal pseudo-obstruction connection by cisapride. Gastroenterology 91: 619–626, 1986PubMedGoogle Scholar
  122. 122.
    Schuffler MD, Deitch EA: Chronic idiopathic intestinal pseudo-obstruction: A surgical approach. Ann Surg 192: 752–761, 1980PubMedGoogle Scholar
  123. 123.
    Pitt HA, Mann LL, Berquist WE, et al: Chronic intestinal pseudo-obstruction: Management with total parenteral nutrition and a venting enterostomy. Arch Surg 120: 614–618, 1985PubMedGoogle Scholar
  124. 124.
    Shaw A, Shaffer HA, Anuras S: Familial visceral myopathy: The role of surgery. Am J Surg 150: 102–108, 1985PubMedGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1989

Authors and Affiliations

  • Paul E. Hyman
    • 1
  1. 1.Division of Pediatric GastroenterologyHarbor—UCLA Medical CenterTorranceUSA

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