Association between Disturbances in Gastrointestinal Transit and Functional Bowel Disease

  • C. D. Lind
  • R. W. McCallum
Part of the Topics in Gastroenterology book series (TGEN)


Although irritable bowel syndrome (IBS) has classically been defined with regard to colonic symptoms,1 mounting evidence points to a diffuse motility disturbance in many patients with IBS.2 Further, as discussed elsewhere in this volume, specific functional disorders of esophageal, gastroduodenal, small intestinal, and colonic motility are being recognized as our ability to measure gastrointestinal electrophysiology, motility, and transit has improved. In this chapter, we will summarize the evidence for altered GI transit in IBS and delineate the relationship, if any, between altered transit of luminal contents and symptoms in IBS. Because of its relationship to IBS, we will also summarize the evidence for stress-related changes in normal GI transit. Finally, treatment regimens which may reverse these disturbances in GI transit, and their associated symptoms, will be discussed.


Irritable Bowel Syndrome Gastric Emptying Corticotropin Release Factor Colonic Transit Colonic Motility 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Publishing Corporation 1989

Authors and Affiliations

  • C. D. Lind
    • 1
  • R. W. McCallum
    • 1
  1. 1.Department of Intemal Medicine, Division of GastroenterologyUniversity of Virginia Medical CenterCharlottesvilleUSA

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