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Regulatory Actions of the Insulin-Like Growth Factor, IGF-I (Somatomedin-C), on Sterol Metabolism by Ovarian Cells

  • Johannes D. Veldhuis

Abstract

Steroidogenic cells require large quantities of sterol substrate for utilization in the biosynthesis and secretion of relevant steroid hormones (1,2). Although the regulation of cholesterol’s economy in ovarian (granulosa and luteal) cells has been characterized extensively for gonadotropic hormones (particularly LH and HCG), fewer studies are available that delineate the nature of trophic growth factor control of sterol delivery to, and utilization by, the steroidogenic apparatus. To examine the mechanisms subserving the actions of differentiating growth factors, we have employed an in vitro serum-free culture system of swine granulosa cells that is highly responsive to the insulin-like growth factor, IGF-I (Somatomedin-C) (3,4).

Keywords

Granulosa Cell Follicular Fluid Trophic Action Porcine Granulosa Cell Differentiate Growth Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Johannes D. Veldhuis
    • 1
  1. 1.Department of Internal Medicine, School of MedicineUniversity of VirginiaCharlottesvilleUSA

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