Abstract
Steroidogenic cells require large quantities of sterol substrate for utilization in the biosynthesis and secretion of relevant steroid hormones (1,2). Although the regulation of cholesterol’s economy in ovarian (granulosa and luteal) cells has been characterized extensively for gonadotropic hormones (particularly LH and HCG), fewer studies are available that delineate the nature of trophic growth factor control of sterol delivery to, and utilization by, the steroidogenic apparatus. To examine the mechanisms subserving the actions of differentiating growth factors, we have employed an in vitro serum-free culture system of swine granulosa cells that is highly responsive to the insulin-like growth factor, IGF-I (Somatomedin-C) (3,4).
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© 1989 Plenum Press, New York
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Veldhuis, J.D. (1989). Regulatory Actions of the Insulin-Like Growth Factor, IGF-I (Somatomedin-C), on Sterol Metabolism by Ovarian Cells. In: Hirshfield, A.N. (eds) Growth Factors and the Ovary. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5688-2_9
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DOI: https://doi.org/10.1007/978-1-4684-5688-2_9
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5690-5
Online ISBN: 978-1-4684-5688-2
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