A Fibronectin Receptor Competitive Blocker Inhibits GnRH Induced Meiosis in Follicle-Enclosed Oocytes

  • M. Yemini
  • R. Tomur
  • T. T. Hung


Mammalian oocytes are arrested at the diplotene stage of the first meiotic division before ovulation and the preovulatory surge of gonadotropin initiates resumption of meiosis (1). Oocyte maturation can also be effectively induced by gonadotropin releasing hormone (GnRH) or GnRH agonist (2). The process which leads to oocyte maturation is probably mediated by follicular components and is not the result of a direct interaction between the female gamete and the hormone (3,4). During the process of follicular growth, a complex sequence of changes occur, including granulosa cells (GCs) differentiation, extracellular matrix (ECM) interaction with the GCs affecting the differentiation as well as the cytoplas-matic and nuclear maturation of the oocyte (1,5). Fibronectin (Fn) is a major component of the ECM and has been implicated in a wide variety of cellular properties, particularly those involving the interaction of cells with ECM (6). Recently, it has been demonstrated that GCs can synthesize and secrete Fn (7,8), and cytodifferentiation of GCs was induced by GnRH which, in turn, promoted Fn secretion (9).


Granulosa Cell Follicular Fluid Oocyte Maturation GnRH Agonist GnRH Analog 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • M. Yemini
    • 1
  • R. Tomur
    • 1
  • T. T. Hung
    • 1
  1. 1.Division of Reproductive Endocrinology and REPSCEND Laboratory, Department of Obstetrics and Gynecology, School of MedicineUniversity of MiamiMiamiUSA

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