Estradiol-Induced Synthesis and Translation of Specific Proteins in the Corpus Luteum
Throughout pregnancy in the rat, several hormones control luteal cell function (1). Following nidation, locally formed estradiol becomes essential for the activation of the steps necessary for optimal steroid production and for the growth and survival of the corpus luteum (1). Estradiol stimulation of luteal growth is accompanied by a remarkable proliferation of vascular endothelial cells. However, in contrast to its effect on other target cells, estradiol does not elicit luteal cell multiplication but rather cell hypertrophy and a marked increase in protein synthesis. Although the action of estradiol on overall protein synthesis is dramatic, its effect on such diverse parameters as steroidogenesis and vascularization strongly suggests that this steroid may stimulate specific proteins which mediate its broad spectrum of action.
KeywordsMigration Sucrose Estrogen EDTA Electrophoresis
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