Evidence for an Endogenous Activator of Inositol Phospholipid Phospholipase C in Intact Rat Corpora Lutea

  • John S. Davis
  • Leigh A. West
  • Laura L. Weakland


The inositol phospholipid-phospholipase C transmembrane signalling system provides second messengers that regulate cellular differentiation as well as metabolic and secretory activities (reviewed in references 1,2). These cellular events are presumably mediated by increases in inositol 1,4,5-trisphosphate and diacylglycerol, the two immediate products of phosphatidylinositol 4,5-bisphosphate hydrolysis. Both products contribute to the cellular activity by regulating intracellular calcium mobilization and the activities of protein kinases.


Corpus Luteum Inositol Phosphate Luteal Cell Inositol Trisphosphate Inositol Phospholipid 


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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • John S. Davis
    • 1
  • Leigh A. West
    • 1
  • Laura L. Weakland
    • 1
  1. 1.Departments of Internal Medicine and Pharmacology and TherapeuticsUniversity of South Florida and J. A. Haley Veterans HospitalTampaUSA

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