Luteinizing Hormone (LH)-Like Activity and Follicle-Stimulating Hormone (FSH) Are Sufficient for the Induction of Cystic Ovaries in Hypophysectomized Rats
Direct evidence for the role of specific peptides in the induction of ovarian cysts has been difficult to obtain. We have shown that chronic stimulation by human chorionic gonadotropin (hCG) induces cysts in intact immature and pregnant rats but not in hypophysectomized (HYPXD) rats (1). Therefore, LH may require at least one other pituitary hormone to induce ovarian cysts. Serum hormone profiles emphasize the complexity of the cystic state (2–4). Yet both women and animals with ovarian cysts display chronically low or normal serum FSH. This study was performed to determine if chronic stimulation by FSH and LH-like activity is sufficient to induce ovarian cysts in HYPXD rats.
KeywordsLuteinizing Hormone Ovarian Cyst Preantral Follicle Chronic Stimulation Follicular Cyst
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