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Growth Factors and the Ovary pp 345–349Cite as

Luteinizing Hormone (LH)-Like Activity and Follicle-Stimulating Hormone (FSH) Are Sufficient for the Induction of Cystic Ovaries in Hypophysectomized Rats

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Abstract

Direct evidence for the role of specific peptides in the induction of ovarian cysts has been difficult to obtain. We have shown that chronic stimulation by human chorionic gonadotropin (hCG) induces cysts in intact immature and pregnant rats but not in hypophysectomized (HYPXD) rats (1). Therefore, LH may require at least one other pituitary hormone to induce ovarian cysts. Serum hormone profiles emphasize the complexity of the cystic state (2–4). Yet both women and animals with ovarian cysts display chronically low or normal serum FSH. This study was performed to determine if chronic stimulation by FSH and LH-like activity is sufficient to induce ovarian cysts in HYPXD rats.

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References

  1. Bogovich K. Induction of follicular cysts in rat ovaries by prolonged administration of human chorionic gonadotropin. In: Mahesh VB, Dhindsa DS, Anderson E, Kalra SP, eds. Regulation of ovarian and testicular function. New York: Plenum Publishing Corp., 1987:659–63.

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Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, School of Medicine, University of South Carolina, Columbia, SC, 29208, USA

    Katryna Bogovich

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  1. Katryna Bogovich
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Editor information

Editors and Affiliations

  1. University of Maryland, Baltimore, Maryland, USA

    Anne N. Hirshfield

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© 1989 Plenum Press, New York

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Bogovich, K. (1989). Luteinizing Hormone (LH)-Like Activity and Follicle-Stimulating Hormone (FSH) Are Sufficient for the Induction of Cystic Ovaries in Hypophysectomized Rats. In: Hirshfield, A.N. (eds) Growth Factors and the Ovary. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5688-2_43

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  • DOI: https://doi.org/10.1007/978-1-4684-5688-2_43

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5690-5

  • Online ISBN: 978-1-4684-5688-2

  • eBook Packages: Springer Book Archive

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