Inhibitory Coupling Between Protein Kinase C and Cyclic AMP Generation in Swine Granulosa Cells

  • Matthew B. Wheeler
  • Johannes D. Veldhuis


The ovarian cyclic AMP (cAMP) effector pathway has been studied extensively with regard to granulosa cell and follicular maturation (1–4). In contrast, the role of the recently described and ubiquitous calcium-sensitive, phospholipid-dependent protein kinase (protein kinase C) effector pathway in ovarian physiology is less well understood. Furthermore, the exact nature of interactions between these two effector systems in the ovary is not known in detail.


Luteinizing Hormone Granulosa Cell Adenylate Cyclase Cholera Toxin cAMP Accumulation 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Matthew B. Wheeler
    • 1
  • Johannes D. Veldhuis
    • 1
  1. 1.Department of Internal MedicineUniversity of Virginia School of MedicineCharlottesvilleUSA

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