Variations in the Interaction Between Follicular Glycosaminoglycans and Fibronectin Relative to the LH Surge in Cattle
Follicle stimulating hormone exerts divergent effects on production of fibronectin (Fn) and proteoglycans by granulosa cells (GC) (1,2). Fn is a glycoprotein constituent of the extracellular matrix and its production decreases when GC are exposed to FSH (3). In contrast, addition of FSH to GC enhances production of high molecular weight proteoglycans. Proteoglycans consist of a core protein with covalently attached glycosaminoglycan (GAG) side-chains (4). GAGs can inhibit gonadotropin binding and steroidogenesis, but the exact loci where those inhibitions occur are not known.
KeywordsLuteinizing Hormone Granulosa Cell Follicular Fluid Large Follicle Luteinizing Hormone Surge
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