Heparin-Binding Proteins in Purified Plasma Membranes of Bovine Granulosa Cells

  • Martin A. Winer
  • Roy L. Ax


During follicular development, granulosa cells produce glycosaminoglycans (GAGs) as constituents which are secreted into follicular fluid (1). GAGs stimulate appearance of gonadotropin receptors on granulosa cells cultured in vitro (2). Conversely, follicular GAGs inhibit gonadotropin binding to cell surface receptors (2,3). They inhibit progesterone secretion (4,5) and may inhibit steroidogenesis indirectly by altering the binding and degradation of lipoproteins (4).


Granulosa Cell Heparan Sulfate Follicular Fluid Follicular Development Isolation Buffer 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Martin A. Winer
    • 1
  • Roy L. Ax
    • 1
  1. 1.Department of Dairy Science and the Endocrinology-Reproductive Physiology ProgramUniversity of WisconsinMadisonUSA

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