Vasoactive Intestinal Peptide (VIP) Has an LH-Like Action on In Vitro Follicular Steroidogenesis But Not on Ovulation in the Cyclic Hamster
In vitro Vasoactive Intestinal Peptide (VIP) (but not Substance P) increases ovarian progesterone (P), androstenedione (A) and estradiol (E2) production in the prepubertal rat (1); the source of P and A was interstitium and/or theca. VIP also stimulates in vitro granulosa cell production of P and E2 (2). The VIP-induced E2 secretion was mediated by an increase in granulosa cell aromatase activity (2). These steroidogenic actions of VIP are similar to FSH and LH. The in vitro effects of VIP on steroidogenesis of various types of follicles, i.e., preantral, preovulatory and atretic, are unknown. Thus, our aims were to determine whether VIP altered steroidogenesis in thecae and/or granulosa cells of follicles in various stages of development.
KeywordsGranulosa Cell Vasoactive Intestinal Peptide Preantral Follicle Atretic Follicle Preovulatory Follicle
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© Plenum Press, New York 1989