Direct Action of Gonadotropin Releasing-Hormone and Visualization of Its Receptors on Porcine Ovaries
Gonadotropin releasing hormone (GnRH) has direct actions on the rat ovary (1). Specific GnRH receptors have been demonstrated on rat (2) and human (3) ovaries. While hypothalamic GnRH is not believed to reach the ovary in sufficient concentration to influence its function, evidence exists for a locally made rat ovarian GnRH-like molecule (4). A GnRH-like molecule may play a role in the local control of follicular response to gonadotropins. Specific receptors for GnRH have not been detected by radioreceptor assays in porcine, equine or bovine ovaries (5). The experiments presented in this paper were aimed at examining whether GnRH or a GnRH-like molecule might play a role in regulation of follicular development in the porcine ovary.
KeywordsGranulosa Cell Follicular Fluid GnRH Agonist Antral Follicle GnRH Receptor
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- 8.Ledwitz-Rigby F, Petito SH, Gross TM, et al. A comparison of the actions of GnRH agonist, antagonist and follicular fluids on granulosa cell progesterone secretion. Excerpta Med Int Cong Ser 1984; 652:903.Google Scholar
- 9.Ledwitz-Rigby F. GnRH analogs alter LH but not FSH stimulation of progesterone secretion by porcine granulosa cells in vitro. Biol Reprod 1986; 34(suppl 1):221.Google Scholar
- 10.Ledwitz-Rigby F, Thau RB (unpublished observations).Google Scholar