Direct Action of Gonadotropin Releasing-Hormone and Visualization of Its Receptors on Porcine Ovaries

  • Florence Ledwitz-Rigby
  • Pamela Dement-Liebenow


Gonadotropin releasing hormone (GnRH) has direct actions on the rat ovary (1). Specific GnRH receptors have been demonstrated on rat (2) and human (3) ovaries. While hypothalamic GnRH is not believed to reach the ovary in sufficient concentration to influence its function, evidence exists for a locally made rat ovarian GnRH-like molecule (4). A GnRH-like molecule may play a role in the local control of follicular response to gonadotropins. Specific receptors for GnRH have not been detected by radioreceptor assays in porcine, equine or bovine ovaries (5). The experiments presented in this paper were aimed at examining whether GnRH or a GnRH-like molecule might play a role in regulation of follicular development in the porcine ovary.


Granulosa Cell Follicular Fluid GnRH Agonist Antral Follicle GnRH Receptor 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Florence Ledwitz-Rigby
    • 1
  • Pamela Dement-Liebenow
    • 1
  1. 1.Department of Biological SciencesNorthern Illinois UniversityDeKalbUSA

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