PMSG Induction of C-Fos and C-Myc Proteins Within Granulosa Cells of Immature Rat Ovaries

  • John J. Peluso
  • Anna Pappalardo


In order for gonadotropins to stimulate granulosa cells, they must first bind to their respective receptors which are located on the surface membrane (1). This binding initiates a cascade of yet undefined events which ultimately leads to a signal being sent to the nucleus which, in turn, induces mitosis and steroidogenesis. These two physiological processes could be the result of differential activation of “mitogenic” and “steroidogenic” gene systems.


Granulosa Cell Porcine Granulosa Cell Unilateral Ovariectomy Entire Ovary Ovarian Follicular Fluid 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • John J. Peluso
    • 1
  • Anna Pappalardo
    • 1
  1. 1.Department of Obstetrics and GynecologyUniversity of Connecticut Health CenterFarmingtonUSA

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