Gonadotropins Enhance the Cytoplasmic Maturation of Mouse Oocytes Under the Influence of Growth Factors
Although germinal vesicle (GV) stage oocytes collected before the gonadotropin surge can resume meiosis relatively easily and reach metaphase II in vitro, the potential for fertilization and embryonic development of these in vitro matured oocytes is usually poor. To understand the role of the gonadotropin surge in controlling the physiological maturation of oocytes, we attempted to mature GV stage mouse oocytes, which had not been exposed to a gonadotropin surge, in medium supplemented by gonadotropins, and then assessed the physiological maturity of the oocytes by examining their potential for fertilization and embryonic development in vitro.
KeywordsOocyte Maturation Genninal Vesicle Mouse Oocyte Blastocyst Development Genninal Vesicle Breakdown
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