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Gonadotropins Enhance the Cytoplasmic Maturation of Mouse Oocytes Under the Influence of Growth Factors

  • Masao Jinno
  • Bruce A. Sandow
  • Rihachi Iizuka
  • Gary D. Hodgen

Abstract

Although germinal vesicle (GV) stage oocytes collected before the gonadotropin surge can resume meiosis relatively easily and reach metaphase II in vitro, the potential for fertilization and embryonic development of these in vitro matured oocytes is usually poor. To understand the role of the gonadotropin surge in controlling the physiological maturation of oocytes, we attempted to mature GV stage mouse oocytes, which had not been exposed to a gonadotropin surge, in medium supplemented by gonadotropins, and then assessed the physiological maturity of the oocytes by examining their potential for fertilization and embryonic development in vitro.

Keywords

Oocyte Maturation Genninal Vesicle Mouse Oocyte Blastocyst Development Genninal Vesicle Breakdown 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Masao Jinno
    • 1
  • Bruce A. Sandow
    • 1
  • Rihachi Iizuka
    • 2
  • Gary D. Hodgen
    • 1
  1. 1.The Jones Institute for Reproductive Medicine, Department of Obstetrics and GynecologyEastern Virginia Medical SchoolNorfolkUSA
  2. 2.Department of Obstetrics and GynecologyKeio University School of MedicineTokyoJapan

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