Maturation of the Oocyte-Cumulus Cell Complex in Mice: Specificity of Epidermal Growth Factor Activity

  • Stephen M. Downs


Fully grown mammalian oocytes within the ovary remain arrested in prophase 1 of meiosis until the preovulatory gonadotropin surge, at which time the resumption of meiotic maturation is stimulated in a specific group of graafian follicles. This event is heralded by dissolution of the nucleus, a process termed germinal vesicle breakdown (GVB). The mechanism by which oocytes are induced to mature in vivo is poorly understood. Because GVB occurs spontaneously when meiotically competent oocytes are removed from the ovary and placed in culture, it appears that the ovary provides inhibitory input that maintains meiotic arrest. Indeed, various follicular fluid components have been shown to suppress the spontaneous maturation of oocytes (1,2).


Epidermal Growth Factor Oocyte Maturation Cumulus Cell Meiotic Maturation Germinal Vesicle Breakdown 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Tsafriri A, Dekel N, Bar-Ami S. J Reprod Fertil 1982; 64:541–51.PubMedCrossRefGoogle Scholar
  2. 2.
    Eppig JJ, Downs SM. In: Haseltine FP, First NL, eds. Meiotic inhibition: molecular control mechanisms. New York: Alan R. Liss, Inc., 1988 (in press).Google Scholar
  3. 3.
    Amsterdam A, Josephs R, Lieberman ME, Lindner HR. J Cell Sci 1976; 21:93–105.PubMedGoogle Scholar
  4. 4.
    Anderson E, Albertini DF. J Cell Biol 1976; 71:680–6.PubMedCrossRefGoogle Scholar
  5. 5.
    Gilula NB, Epstein ML, Beers WH. J Cell Biol 1978; 78:58–75.PubMedCrossRefGoogle Scholar
  6. 6.
    Moor RM, Osborn JC, Cran DG, Walters DE. J Embryol Exp Morphol 1981; 61:347–65.PubMedGoogle Scholar
  7. 7.
    Eppig JJ. Dev Biol 1981; 89:268–72.CrossRefGoogle Scholar
  8. 8.
    Larsen WJ, West SE, Brunner GD. Dev Biol 1986; 113:517–21.PubMedCrossRefGoogle Scholar
  9. 9.
    Dekel N, Beers WH. Proc Natl Acad Sci USA 1978; 75:4369–73.PubMedCrossRefGoogle Scholar
  10. 10.
    Dekel N, Beers WH. Dev Biol 1980; 75:247–54.PubMedCrossRefGoogle Scholar
  11. 11.
    Downs SM, Daniel SAJ, Eppig JJ. J Exp Zool 1988; 245:86–96.PubMedCrossRefGoogle Scholar
  12. 12.
    Eppig JJ, Downs SM. Dev Biol 1986; 119:313–21.CrossRefGoogle Scholar
  13. 13.
    Feng P, Catt KJ, Knecht M. Endocrinology 1988; 122:181–6.PubMedCrossRefGoogle Scholar
  14. 14.
    Downs SM, Eppig JJ. Gamete Res 1985; 11:83–97.CrossRefGoogle Scholar
  15. 15.
    Eppig JJ. J Exp Zool 1979; 208:111–20.PubMedCrossRefGoogle Scholar
  16. 16.
    Dekel N, Phillips DM. Biol Reprod 1980; 22:289–96.PubMedCrossRefGoogle Scholar
  17. 17.
    Downs SM. Biol Reprod 1988; 38(suppl 1):67 (Abstract 57).Google Scholar
  18. 18.
    Nishizuka Y, Takai Y, Kishimoto A, Kikkawa U, Kaibuchi K. Recent Prog Horm Res 1984;40:301–45.PubMedGoogle Scholar
  19. 19.
    Aberdam E, Dekel N. Biochem Biophys Res Commun 1985; 132:570–4.PubMedCrossRefGoogle Scholar
  20. 20.
    Tsafriri A, Bar-Ami S. J Exp Zool 1978; 205:293–9.PubMedCrossRefGoogle Scholar
  21. 21.
    Powers RD, Paleos GA. J Reprod Fertil 1982; 66:1–8.PubMedCrossRefGoogle Scholar
  22. 22.
    Racowsky C. J Exp Zool 1986; 239:263–75.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Stephen M. Downs
    • 1
  1. 1.Biology Department, Biological and Biomedical Research InstituteMarquette UniversityMilwaukeeUSA

Personalised recommendations