Steroidogenic Effect of Insulin May Not Be Mediated Through Somatomedin-C/IGF-I Receptors
Insulin and Somatomedin-C/insulin-like growth factor-I (IGF-I) are capable of eliciting selective differentiative changes in ovarian granulosa cells of several species including growth promotion, enhanced steroidogenesis and induction of luteinizing hormone (LH) receptors (1–3). Insulin and IGF-I can also amplify the stimulatory effects of classical ovarian effector hormones and low-density lipoproteins (LDL) on progesterone (P4) biosynthesis in ovarian cells (3–5). IGF-I receptors have recently been shown to be present, and it is possible that the action of insulin may be mediated through the IGF-I receptors (2).
KeywordsGrowth Hormone Luteinizing Hormone Granulosa Cell Ovarian Granulosa Cell Progesterone Secretion
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- 3.Maruo T, Hayashi M, Matsuo H, Ueda Y, Morikawa H, Mochizuki M. Comparison of facilitative roles of insulin and insulin-like growth factor-1 in the functional differentiation of granulosa cells; in vitro studies with the porcine model. Acta Endocrinol (Copenh) 1988; 117:230–40.Google Scholar
- 14.Otani T, Maruo T, Mochizuki M. Effect of insulin on porcine granulosa cells: implication of a possible receptor mediated action. Acta Endocrinol (Copenh) 1985; 108:104–10.Google Scholar