Steroidogenic Effect of Insulin May Not Be Mediated Through Somatomedin-C/IGF-I Receptors

  • A. D. Gooneratne
  • P. A. Thacker
  • B. Laarveld
  • B. D. Murphy
  • K. Rajkumar


Insulin and Somatomedin-C/insulin-like growth factor-I (IGF-I) are capable of eliciting selective differentiative changes in ovarian granulosa cells of several species including growth promotion, enhanced steroidogenesis and induction of luteinizing hormone (LH) receptors (1–3). Insulin and IGF-I can also amplify the stimulatory effects of classical ovarian effector hormones and low-density lipoproteins (LDL) on progesterone (P4) biosynthesis in ovarian cells (3–5). IGF-I receptors have recently been shown to be present, and it is possible that the action of insulin may be mediated through the IGF-I receptors (2).


Growth Hormone Luteinizing Hormone Granulosa Cell Ovarian Granulosa Cell Progesterone Secretion 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • A. D. Gooneratne
    • 1
  • P. A. Thacker
    • 1
  • B. Laarveld
    • 1
  • B. D. Murphy
    • 2
  • K. Rajkumar
    • 2
  1. 1.Department of Animal and Poultry ScienceUniversity of SaskatchewanSaskatoonCanada
  2. 2.Department of Obstetrics and GynecologyUniversity of SaskatchewanSaskatoonCanada

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