Growth Factor-Gonadotropin Interactions in Ovarian Cells

  • David W. Schomberg


The literature now contains several publications demonstrating that classical reproductive hormones and growth factors interact to modulate ovarian cellular function (see reviews 1–3). Examples on a general level are: (1) regulation by reproductive hormones of growth factor production; (2) modulation of growth factor receptor expression/function by reproductive hormones; or conversely, (3) modulation of the production of reproductive hormones by growth factors; and, (4) growth factor involvement in regulating the expression/function of receptors for reproductive hormones. However, detailed biochemical knowledge in terms of the intracellular mechanisms by which these various effectors interact to regulate growth or differentiation is not yet available for any cell type. Also, at this level, there is no information to indicate whether growth factor-initiated mechanisms are the same in reproductive hormone-responsive vs. nonresponsive cells.


Granulosa Cell Follicular Fluid Reproductive Hormone Luteinizing Hormone Receptor Preantral Follicle 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • David W. Schomberg
    • 1
  1. 1.Departments of Obstetrics and Gynecology and Cell BiologyDuke University Medical CenterDurhamUSA

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