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Growth Factor-Gonadotropin Interactions in Ovarian Cells

  • David W. Schomberg

Abstract

The literature now contains several publications demonstrating that classical reproductive hormones and growth factors interact to modulate ovarian cellular function (see reviews 1–3). Examples on a general level are: (1) regulation by reproductive hormones of growth factor production; (2) modulation of growth factor receptor expression/function by reproductive hormones; or conversely, (3) modulation of the production of reproductive hormones by growth factors; and, (4) growth factor involvement in regulating the expression/function of receptors for reproductive hormones. However, detailed biochemical knowledge in terms of the intracellular mechanisms by which these various effectors interact to regulate growth or differentiation is not yet available for any cell type. Also, at this level, there is no information to indicate whether growth factor-initiated mechanisms are the same in reproductive hormone-responsive vs. nonresponsive cells.

Keywords

Granulosa Cell Follicular Fluid Reproductive Hormone Luteinizing Hormone Receptor Preantral Follicle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Adashi EY, Resnick CE, D’Ercole AJ, Svoboda ME, Van Wyk JJ. Insulin-like growth factors as intraovarian regulators of granulosa cell growth and function. Endocr Rev 1985; 6:400.PubMedCrossRefGoogle Scholar
  2. 2.
    Schomberg DW. Regulation of follicle development by gonadotropins and growth factors. In: Stouffer RL, ed. The Primate Ovary. New York: Plenum Press, 1987:25–33.CrossRefGoogle Scholar
  3. 3.
    Schomberg DW. The role of growth factors in the regulation of ovarian growth and function. In: Parvinen M, Huhtaniemi I, Pelliniem LJ, eds. Rome: Ares-Serono Symposia, 1988:127–38.Google Scholar
  4. 4.
    Mondschein JS, Schomberg DW. Growth factors modulate gonadotropin receptor induction in granulosa cell cultures. Science 1981; 211:1179–80.PubMedCrossRefGoogle Scholar
  5. 5.
    Mondschein JS, Schomberg DW. Effects of partially and more highly purified platelet-derived growth factor preparations on luteinizing hormone receptor induction in granulosa cell cultures. Biol Reprod 1984; 30:603–8.PubMedCrossRefGoogle Scholar
  6. 6.
    Heldin CH, Westermark B, Wasteson A. Platelet-derived growth factor: purification and partial characterization. PNAS (USA) 1979; 76:3722–6.CrossRefGoogle Scholar
  7. 7.
    Blair EI, Kim I-C, Estes JE, Keski-Oja J, Schomberg DW. Human PDGF preparations contain a separate activity which potentiates FSH-mediated induction of LH receptor in cultured rat granulosa cells: evidence for transforming growth factor beta. Endocrinology (in press).Google Scholar
  8. 8.
    Knecht M, Catt KJ. Modulation of cAMP-mediated differentiation in ovarian granulosa cells by epidermal growth factor and platelet-derived growth factor. J Biol Chem 1983; 258:2789–94.PubMedGoogle Scholar
  9. 9.
    May JV, Frost JP, Schomberg DW. Differential effects of epidermal growth factor, somatomedin-C/insulin-like growth factor I, and transforming growth factor-β on porcine granulosa cell deoxyribonucleic acid synthesis and cell proliferation. Endocrinology 1988; 123:168–79.PubMedCrossRefGoogle Scholar
  10. 10.
    Goustin AS, Betsholz C, Pfeifer-Ohlsson S, et al. Coexpression of the sis and myc protooncogenes in developing human placenta suggests autocrine control of trophoblastic growth. Cell 1985; 41:301.PubMedCrossRefGoogle Scholar
  11. 11.
    Skinner MK, Keski-Oja J, Osteen KG, Moses HL. Ovarian thecal cells produce transforming growth factor-beta which can regulate granulosa cell growth. Endocrinology 1987; 121:786–92.PubMedCrossRefGoogle Scholar
  12. 12.
    Hernandez ER, Twardzik DR, Purchio A, Adashi EY. Gonadotropin-dependent ovarian transforming growth factor-beta gene expression. Biol Reprod 1987; 36(suppl 1):58.Google Scholar
  13. 13.
    Ruegseggar Veit C, Assoian RK. Identification of transforming growth factor-beta in human ovarian follicular fluid [Abstract]. Abstract No. 1225, Proc 70th Ann Meeting of The Endocrine Society, New Orleans, 1988.Google Scholar
  14. 14.
    Miyazono K, Hellman U, Wemstedt C, Heldin C-H. Latent high molecular weight complex of transforming growth factor B1. J Biol Chem 1988; 263:6407–15.PubMedGoogle Scholar
  15. 15.
    Wakefield LM, Smith DM, Flanders KC, Sporn MB. Latent transforming growth factor-β from human platelets. J Biol Chem 1988; 263:7646–54.PubMedGoogle Scholar
  16. 16.
    Van Obberghen-Schilling E, Roche N, Flanders KC, Sporn MB, Roberts AB. Transforming growth factor Bl positively regulates its own expression in normal and transformed cells. J Biol Chem 1988; 263:7741–6.PubMedGoogle Scholar
  17. 17.
    Knabbe C, Lippman ME, Wakefield LM, et al. Evidence that transforming growth factor-beta is a hormonally regulated negative growth factor in human breast cancer cells. Cell 1987; 48:417–28.PubMedCrossRefGoogle Scholar
  18. 18.
    Ikeda T, Lioubin MN, Marquardt H. Human transforming growth factor type B2: production by a prostatic adenocarcinoma cell line, purification, and initial characterization. Biochemistry 1988; 26:2406–10.CrossRefGoogle Scholar
  19. 19.
    Lawrence DA, Pircher R, Jullien P. Conversion of a high molecular weight latent β-TGF from chicken embryo fibroblasts into a low molecular weight active β-TGF under acidic conditions. Biochem Biophys Res Commun 1985; 133:1026–34.PubMedCrossRefGoogle Scholar
  20. 20.
    Sporn MB, Roberts AB, Wakefield LM, Assoian RK. Transforming growth factor-β: biological function and chemical structure. Science 1986; 233:532–4.PubMedCrossRefGoogle Scholar
  21. 21.
    Dorrington JA, Chuma V, Bendell JJ. Transforming growth factor β and follicle-stimulating hormone promote rat granulosa cell proliferation. Endocrinology 1988; 123:353–9.PubMedCrossRefGoogle Scholar
  22. 22.
    Knecht M, Feng P, Catt KJ. Transforming growth factor-beta regulates the expression of luteinizing hormone receptors in ovarian granulosa cells. Biochem Biophys Res Commun 1986; 139:800–7.PubMedCrossRefGoogle Scholar
  23. 23.
    Dodson WC, Schomberg DW. The effect of transforming growth factor-β on follicle-stimulating hormone-induced differentiation of cultured rat granulosa cells. Endocrinology 1987; 120:512–6.PubMedCrossRefGoogle Scholar
  24. 24.
    Adashi EY, Resnick CE. Antagonistic interactions of transforming growth factors in the regulation of granulosa cell differentiation. Endocrinology 1986; 119:1879–81.PubMedCrossRefGoogle Scholar
  25. 25.
    Knecht M, Feng P, Catt KJ. Bifunctional role of transforming growth factor-β during granulosa cell development. Endocrinology 1987; 120:1243–9.PubMedCrossRefGoogle Scholar
  26. 26.
    Cheifetz S, Weatherbee JA, Tsang M L-S, et al. The transforming growth factor-β system, a complex pattern of cross-reactive ligands and receptors. Cell 1987; 48:409–15.PubMedCrossRefGoogle Scholar
  27. 27.
    Markovac J, Goldstein GW. Transforming growth factor beta activates protein kinase C in microvessels isolated from immature rat brain. Biochem Biophys Res Commun 1988; 150:575–82.PubMedCrossRefGoogle Scholar
  28. 28.
    Libby J, Martinez R, Weber MJ. Tyrosine phosphorylation in cells treated with transforming growth factor-β. J Cell Physiol 1986; 129:159–66.PubMedCrossRefGoogle Scholar
  29. 29.
    Kim I-C, May JV, Schomberg DW. The potential mechanism by which human transforming growth factor-β (hTGF-β) modulates FSH-induced differentiation of cultured rat granulosa cells (GC) [Abstract No. 237]. Biol Reprod 1987; 36(suppl 1):125.CrossRefGoogle Scholar
  30. 30.
    Gospodarowicz D, Ill CR, Birdwell CR. Effects of fibroblast and epidermal growth factors on ovarian cell proliferation in vitro. I. Characterization of the response of granulosa cells to FGF and EGF. Endocrinology 1977; 100:1108–20.PubMedCrossRefGoogle Scholar
  31. 31.
    Gospodarowicz D, Mescher AL, Birdwell CR. Control of cellular proliferation by the fibroblast and epidermal growth factors. In: Third decennial review conference: cell, tissue, and organ culture. National Cancer Institute Monograph 48. Bethesda: USPHS, NIH 1978:109–30.Google Scholar
  32. 32.
    Shaw G, Jorgenson GI, Tweendale R, Tennison M, Waters MJ. Effect of epidermal growth factor on reproductive function of ewes. J Endocrinol 1985; 107:429–36.PubMedCrossRefGoogle Scholar
  33. 33.
    Radford HM, Panaretto BA, Avenell JA, Turnbull KE. Effect of mouse epidermal growth factor on plasma concentrations of FSH, LH, and progesterone and on oestrus, ovulation and ovulation rate in merino ewes. J Reprod Fertil 1987; 80:383–8.PubMedCrossRefGoogle Scholar
  34. 34.
    Rall LB, Scott J, Bell GI. Mouse preproepidermal growth factor synthesis by the kidney and other tissues. Nature 1985; 313:228–30.PubMedCrossRefGoogle Scholar
  35. 35.
    Hsu C-J, Holmes SD, Hammond JM. Ovarian epidermal growth factor-like activity. Concentrations in porcine follicular fluid during follicular development. Biochem Biophys Res Commun 1987; 147:242–7.PubMedCrossRefGoogle Scholar
  36. 36.
    Skinner MK, Lobb D, Dorrington JH. Ovarian thecal/interstitial cells produce an epidermal growth factor-like substance. Endocrinology 1987; 121:1892–9.PubMedCrossRefGoogle Scholar
  37. 37.
    Kudlow JE, Kobrin MS, Purchio AF, et al. Ovarian transforming growth factor-alpha gene expression: immunohistochemical localization to the theca-interstitial cells. Endocrinology 1987; 121:1577–9.PubMedCrossRefGoogle Scholar
  38. 38.
    Lobb DK, Skinner MK, Dorrington JH. Rat thecal/interstitial cells produce a mitogenic activity that promotes the growth of granulosa cells. Mol Cell Endocrinol 1988; 55:209–17.PubMedCrossRefGoogle Scholar
  39. 39.
    Jones PBC, Welsh TH Jr, Hsueh AJW. Regulation of ovarian progestin production by epidermal growth factor in cultured rat granulosa cells. J Biol Chem 1982; 257:11268–73.PubMedGoogle Scholar
  40. 40.
    Feng P, Knecht M, Catt KJ. Hormonal control of epidermal growth factor receptors by gonadotropins during granulosa cell differentiation. Endocrinology 1987; 120:1121–6.PubMedCrossRefGoogle Scholar
  41. 41.
    Buck PA, Schomberg DW. [125I]iodo-epidermal growth factor binding and mitotic responsiveness of porcine granulosa cells are modulated by differentiation and follicle-stimulating hormone. Endocrinology 1988; 122:28–33.PubMedCrossRefGoogle Scholar
  42. 42.
    May JV, Buck PA, Schomberg DW. Epidermal growth factor enhances [I]iodo-follicle stimulating hormone binding by cultured porcine granulosa cells. Endocrinology 1987; 120:2413–20.PubMedCrossRefGoogle Scholar
  43. 43.
    Roy SK, Greenwald GS. Quantitative analysis of in vitro incorporation of [H]thymidine into hamster follicles during the oestrous cycle. J Reprod Fert 1986; 77:143–52.CrossRefGoogle Scholar
  44. 44.
    Hirshfield AN, Schmidt WA. Kinetic aspects of follicular development in the rat. In: Mahesh VB, Dhindsa DS, Anderson E, Kalia SP, eds. Regulation of ovarian and testicular function. New York: Plenum, 1987:211–36.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • David W. Schomberg
    • 1
  1. 1.Departments of Obstetrics and Gynecology and Cell BiologyDuke University Medical CenterDurhamUSA

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