Transcriptional Diversity in Rat Insulin-Like Growth Factor I Gene Expression
Insulin-like growth factor I (IGF-I), or Somatomedin C, is a member of a family of insulin-like peptides which also includes insulin itself, insulin-like growth factor II (IGF-II) or multiplication-stimulating activity (MSA), and, in some schemes, relaxin (1,2,3). The IGFs are similar to proinsulin in that they contain B and A domains separated by a C peptide sequence, but differ in that the mature IGF-I proteins retain their C peptide moeities and therefore consist of single polypeptide chains. Additionally, the mature forms of the IGFs contain a carboxy-terminal D domain not found in insulin (2,4,5). Finally, as discussed in more detail below with respect to IGF-I, cDNA sequences corresponding to IGF-I and IGF-II mRNAs suggest the presence of an additional carboxy-terminal E peptide predicted to be a component of the IGF-I and IGF-II pro-hormones (6,7,8,9).
KeywordsTranscriptional Diversity Multiple Size Classis Signal Peptide Amino Acid Sequence
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