The Structure and Expression of the Human Insulin-Like Growth Factor Genes

  • Pieternella Holthuizen


The insulin-like growth factors (IGF) are a group of peptides involved in mammalian growth and development (37). The complete structures of two major species were first elucidated by Rinderknecht and Humbel (27,28). IGF-I is a basic peptide of 70 amino acids which mediates the growth promoting action of growth hormone and plays an important role in postnatal growth. The biological action of IGF-II, a 67 amino acids long peptide, is less obvious. It is thought to stimulate a variety of growth promoting processes in the fetus but several studies also indicate a function for IGF-II in the postnatal stage (4).


Adult Liver cDNA Library 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Pieternella Holthuizen
    • 1
  1. 1.Laboratory for Physiological ChemistryState University of UtrechtUtrechtThe Netherlands

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