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Growth Hormone and IGF Abnormalities of the African Pygmy

  • Thomas J. Merimee

Abstract

Since the elucidation of the structures of insulin-like growth factors I and II (IGF I and IGF II) by Humbel1,2, and the development of specific radioimmunoassays for each by Zapf and Froesch3, a number of clinical conditions have been identified that are associated with defects in either the secretion or action of these agents4,5. After 25 years of investigating stature of the African pygmy, data have now been obtained indicating a unique genetic variation in the GH-IGF I axis in these subjects. These data will be presented in this article.

Keywords

Growth Hormone Growth Hormone Receptor Plasma Free Fatty Acid Concentration Growth Hormone Receptor Gene Unique Genetic Variation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Thomas J. Merimee
    • 1
  1. 1.Department of Medicine, Division of Endocrinology and Metabolism, JHMHCUniversity of FloridaGainesvilleUSA

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