Interactions of Insulin and IGFS with Cellular Components of the Arterial Wall: Potential Impact on Atherosclerosis

  • Robert S. Bar
  • William L. LoweJr.
  • Robert G. Spanheimer


Insulin and the insulin—like growth factors (IGFs) have a diverse and complicated array of functions in endothelial cells, smooth muscle cells and fibroblasts, three major cell components of the arterial wall. In this chapter, we will review the in vitro studies assessing insulin/IGF effects on these three cell types and introduce other factors which may modulate the action of insulin/IGF on the arterial wall both in normal physiology and in the disease process atherosclerosis.


Vascular Smooth Muscle Cell Insulin Receptor Thymidine Incorporation Smooth Muscle Cell Proliferation Insulin Binding 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Robert S. Bar
    • 1
  • William L. LoweJr.
    • 1
  • Robert G. Spanheimer
    • 1
  1. 1.Veterans Administration Hospital, Diabetes and Endocrinology Research Center, Department of Internal MedicineThe University of IowaIowa CityUSA

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