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Role of Insulin-Like Growth Factor I And II on Skeletal Remodeling

  • Ernesto Canalis
  • Michael Centrella
  • Thomas L. McCarthy

Abstract

The two major processes involved in bone remodeling are bone formation and bone resorption, and these two functions are regulated by systemic hormones and by local growth factors (1,2). Hormones seem to act on skeletal cells either directly or indirectly by modulating the synthesis or effects of local factors, which in turn stimulate or inhibit bone formation or bone resorption. Growth factors can affect bone remodeling either by increasing the number of cells or by affecting the differentiated phenotype of cells of the osteoblast or osteoclast lineage.

Keywords

Cell Replication Bone Collagen Local Growth Factor Cell BioI Skeletal Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    E. Canalis, The hormonal and local regulation of bone formation, Endocr. Rev. 4:62 (1983).PubMedCrossRefGoogle Scholar
  2. 2.
    E. Canalis, T. McCarthy and M. Centrella, Growth factors and the regulation of bone remodeling, J. Clin. Invest. 81:277 (1988).PubMedCrossRefGoogle Scholar
  3. 3.
    P. V. Hauschka, A. E. Mavrakos, M. D. Iafrati, S. E. Doleman and M. Klagsbrun, Growth factors in bone matrix, J. Biol. Chem. 261:12665 (1986)PubMedGoogle Scholar
  4. 4.
    S. M. Seyedin, A. Y. Thompson, H. Bentz, D. M. Rosen, J. M. McPherson, A. Conti, N. R., Siegel, G. R. Galluppi, and K. A. Piez, Cartilage inducing factor. Apparent identity to transforming growth factor-3, J. Biol. Chem. 261:5693 (1986).PubMedGoogle Scholar
  5. 5.
    C. A. Frolik, L. F. Ellis and D. C. Williams, Isolation and characterization of insulin-like growth factor-II from human bone, Biochem. Biophys. Res. Commun. 151:1011 (1988).CrossRefGoogle Scholar
  6. 6.
    S. Mohan, J. C. Jennings, T. A. Linkhart and D. J. Baylink, Primary structure of human skeletal growth factor: homology with human insulin-like growth factor II, Biochem. Biophys. Acta 966:44 (1988).CrossRefGoogle Scholar
  7. 7.
    E. Canalis, T. McCarthy and M. Centrella, Isolation of growth factors from adult bovine bone, Calcif. Tissue. Int. (1988) (In Press).Google Scholar
  8. 8.
    M. R. Urist, R. J. DeLange and G. A. M. Finerman, Bone cell differentiation and growth factors, Science 220:680 (1983).PubMedCrossRefGoogle Scholar
  9. 9.
    E. Canalis, T. McCarthy and M. Centrella, Isolation and characterization of insulin-like growth factor I (Somatomedin-C) from cultures of fetal rat calvariae, Endocrinology 122:22 (1988).PubMedCrossRefGoogle Scholar
  10. 10.
    P. Gehron Robey, M. F. Young, K. C. Flanders, N. S. Roche, P. Kondaiah, A. H. Reddi, J. D. Termine, M. B. Sporn and A. B. Roberts, Osteoblasts synthesize and respond to transforming growth factor-type β (TGF-β) in vitro, J. Cell Biol. 105:457 (1987).PubMedCrossRefGoogle Scholar
  11. 11.
    T. L. McCarthy, M. Centrella, and E. Canalis, Parathyroid hormone enhances the transcript and polypeptide levels of insulin-like growth factor I in osteoblast-enriched cultures from fetal rat bone, Endocrinology (1989) (In Press)Google Scholar
  12. 12.
    M. Ernst and E. R. Froesch, Growth hormone dependent stimulation of osteoblast-like cells in serum-free cultures via local synthesis of insulin-like growth factor I, Biochem. Biophys. Res. Commun. 151:142 (1988).CrossRefGoogle Scholar
  13. 13.
    M. Ernst, C. Schmid, J. Zapf and E. R. Froesch, Osteoblasts synthesize specific carrier proteins for insulin-like growth factor in response to growth hormone and estradiol in vitro, J. Bone Min. Res. 3 Suppl 1 S206 (1988).Google Scholar
  14. 14.
    A. Bennett, T. Chen, D. Feldman, R. Hintz and R. G. Rosenfeld, Characterization of insulin-like growth factor I receptors on cultured rat bone cells: Regulator of receptor concentration by glucocorticoids, Endocrinology 115:1577 (1984).PubMedCrossRefGoogle Scholar
  15. 15.
    E. Canalis, Effect of glucocorticoids on type I collagen synthesis, alkaline phosphatase activity and deoxyribonucleic acid content in cultured rat calvariae, Endocrinology 112:931 (1983).PubMedCrossRefGoogle Scholar
  16. 16.
    M. Binoux, P. Hossenlopp, S. Hardouin, D. Seurin, C. Lassarre and M. Gourmelen, Somatomedin (insulin-like growth factor)-binding proteins. Molecular forms and regulation, Horm. Res. 24:141 (1986).Google Scholar
  17. 17.
    T. L. McCarthy, M. Centrella, and E. Canalis, Regulatory effects of insulin-like growth factor I and II on bone collagen synthesis in rat calvarial cultures, Endocrinology (1989) (In Press)Google Scholar
  18. 18.
    J. M. Hock, M. Centrella, and E. Canalis, Insulin-like growth factor I has independent effects on bone matrix formation and cell replication, Endocrinology 122:254 (1988)PubMedCrossRefGoogle Scholar
  19. 19.
    E. Canalis, and J. Lian, Effects of bone associated growth factors on DNA, collagen and osteocalcin synthesis in cultured fetal rat calvariae, Bone 9:243 (1988)PubMedCrossRefGoogle Scholar
  20. 20.
    M. Centrella, T. L. McCarthy and E. Canalis, Discrete high molecular weight IGF-I and IGF-II receptors in osteoblast-enriched cultures from fetal rat bone, J. Cell Biol. (1989) Abstract (In Press)Google Scholar

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Ernesto Canalis
    • 1
    • 2
  • Michael Centrella
    • 1
    • 2
  • Thomas L. McCarthy
    • 1
    • 2
  1. 1.Medical CenterSt. Francis HospitalHartfordUSA
  2. 2.The University of Connecticut Health CenterFarmingtonUSA

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