Role of Insulin-Like Growth Factor I And II on Skeletal Remodeling

  • Ernesto Canalis
  • Michael Centrella
  • Thomas L. McCarthy


The two major processes involved in bone remodeling are bone formation and bone resorption, and these two functions are regulated by systemic hormones and by local growth factors (1,2). Hormones seem to act on skeletal cells either directly or indirectly by modulating the synthesis or effects of local factors, which in turn stimulate or inhibit bone formation or bone resorption. Growth factors can affect bone remodeling either by increasing the number of cells or by affecting the differentiated phenotype of cells of the osteoblast or osteoclast lineage.


Cell Replication Bone Collagen Local Growth Factor Cell BioI Skeletal Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Ernesto Canalis
    • 1
    • 2
  • Michael Centrella
    • 1
    • 2
  • Thomas L. McCarthy
    • 1
    • 2
  1. 1.Medical CenterSt. Francis HospitalHartfordUSA
  2. 2.The University of Connecticut Health CenterFarmingtonUSA

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