Insulin-Like Growth Factors and Heart Development

  • Gary L. Engelmann
  • Joyce F. Haskell
  • Keith D. Boehm


Growth of the adult mammalian ventricular myocyte (cardiomyocyte) is the topic of considerable interest since heart muscle cells rapidly respond to increases in functional demands by an increase in cellular mass(l). Although the cardiomyocyte of the adult ventricle occupies up to 90% of the area of the left ventricle (LV) free wall, these cells comprise a unique population of a permanently post-mitotic, structurally and functionally delimited cell type that can only expand in width (primarily) and length to increasing functional demand on this vital organ. Therefore, the adult cardiomyocyte population is a static number of muscle cells that define the life-long structure and function of the ventricular portion of the heart. It is the function of the cardiomyocytes that can then be modulated by adjacent cell types (i.e., fibroblasts and endothelium), blood vessels (capillaries and arterioles) and neural/humoral stimuli in the mature organ.


Heart Development Neonatal Development Neonatal Heart Cell BioI Specific Growth Factor Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Gary L. Engelmann
    • 1
  • Joyce F. Haskell
    • 2
  • Keith D. Boehm
    • 3
  1. 1.Research InstituteCleveland Clinic FoundationUSA
  2. 2.Department of Obstetrics and GynecologyUniversity of Alabama at BirminghamUK
  3. 3.Department of Reproductive BiologyCase Western Reserve UniversityUSA

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