Insulin-Like Growth Factors as Regulatory Peptides in the Adult Rat Brain
Much of the present understanding of the actions of IGF-1 and IGF-2 in nervous tissue has come from in vitro studies using either primary brain cultures derived from fetal or neonatal material, or derived CNS cell lines such as neuroblastomas or gliomas. This line of research has established a potential role for the IGFs as growth factors in the developing nervous system, where it has been proposed that they stimulate neuronal sprouting and synaptogenesis (1–4), and induce glial proliferation (5).
KeywordsChoroid Plexus Inositol Phosphate Median Eminence Quantitative Autoradiography Primary Brain Culture
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