Expression of the IGF-II Gene in Brain and Muscle

  • Kenneth M. Rosen
  • Bruce M. Wentworth
  • Edward D. Lamperti
  • Stanislaus Kinota
  • Richard O’Brien
  • Nadia Rosenthal
  • Bruce Yankner
  • Lydia Villa-Komaroff


The insulin-like growth factors (IGFs) have been implicated in many processes related to growth and development. Despite a growing interest by many investigators into the biological role of the insulin-like growth factors, their function remains poorly understood. Advances in molecular biological techniques have allowed for the characterization of the genes for these factors, and provided tools with which to study their expression. Using these tools, investigators have been elucidating the pattern of IGF gene expression in various tissues throughout a wide range of species. We have examined the expression of insulin-like growth factor II (IGF-II) during development in the nervous system and in muscle. IGF-II gene expression is developmentally regulated in both sites, suggesting that it plays an important role during the developmental program.


Nerve Growth Factor Cerebral Spinal Fluid Myogenic Cell Line Skeletal Muscle Cell Line Human Cerebral Spinal Fluid 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Kenneth M. Rosen
    • 1
  • Bruce M. Wentworth
    • 2
  • Edward D. Lamperti
    • 1
    • 3
  • Stanislaus Kinota
    • 1
  • Richard O’Brien
    • 1
  • Nadia Rosenthal
    • 2
  • Bruce Yankner
    • 1
  • Lydia Villa-Komaroff
    • 1
  1. 1.Department of NeurologyThe Children’s Hospital and Harvard Medical SchoolBostonUSA
  2. 2.Department of BiochemistryBoston University Medical SchoolUSA
  3. 3.Department of Cell BiologyUniversity of Massachusetts Medical SchoolUSA

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