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Molecular and Cellular Biology of Insulin-like Growth Factors and Their Receptors pp 219–229Cite as

Expression of the IGF-II Gene in Brain and Muscle

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Abstract

The insulin-like growth factors (IGFs) have been implicated in many processes related to growth and development. Despite a growing interest by many investigators into the biological role of the insulin-like growth factors, their function remains poorly understood. Advances in molecular biological techniques have allowed for the characterization of the genes for these factors, and provided tools with which to study their expression. Using these tools, investigators have been elucidating the pattern of IGF gene expression in various tissues throughout a wide range of species. We have examined the expression of insulin-like growth factor II (IGF-II) during development in the nervous system and in muscle. IGF-II gene expression is developmentally regulated in both sites, suggesting that it plays an important role during the developmental program.

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Authors and Affiliations

  1. Department of Neurology, The Children’s Hospital and Harvard Medical School, 300 Longwood Ave., Boston, MA, 02115, USA

    Kenneth M. Rosen, Edward D. Lamperti, Stanislaus Kinota, Richard O’Brien, Bruce Yankner & Lydia Villa-Komaroff

  2. Department of Biochemistry, Boston University Medical School, USA

    Bruce M. Wentworth & Nadia Rosenthal

  3. Department of Cell Biology, University of Massachusetts Medical School, USA

    Edward D. Lamperti

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  1. Kenneth M. Rosen
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  2. Bruce M. Wentworth
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  3. Edward D. Lamperti
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  4. Stanislaus Kinota
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  5. Richard O’Brien
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  6. Nadia Rosenthal
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  7. Bruce Yankner
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  8. Lydia Villa-Komaroff
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Editors and Affiliations

  1. National Institutes of Health, Bethesda, Maryland, USA

    Derek LeRoith

  2. University of Florida, Gainesville, Florida, USA

    Mohan K. Raizada

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© 1989 Plenum Press, New York

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Rosen, K.M. et al. (1989). Expression of the IGF-II Gene in Brain and Muscle. In: LeRoith, D., Raizada, M.K. (eds) Molecular and Cellular Biology of Insulin-like Growth Factors and Their Receptors. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5685-1_19

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  • DOI: https://doi.org/10.1007/978-1-4684-5685-1_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5687-5

  • Online ISBN: 978-1-4684-5685-1

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