Regulation of IGF-II Gene Expression in Human Adrenals, Gonads and Placenta

  • Raimo Voutilainen


Insulin-like growth factor I (IGF-I) is a 70-amino acid polypeptide mediating some of the somatotrophic effects of growth hormone. IGF-I is produced in many tissues, suggesting that it may function in an autocrine or paracrine fashion (D’Ercole et al., 1984 and 1986; Bell et al. 1985; Lund et al., 1986; Han et al. 1987a and b). Expression of IGF-I gene in the liver is regulated by growth hormone (Mathews et al., 1986; Roberts et al., 1986).


Granulosa Cell Steroidogenic Enzyme Leydig Cell Tumor Dibutyryl cAMP Human Granulosa Cell 


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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Raimo Voutilainen
    • 1
  1. 1.Department of Pediatrics and PathologyUniversity of HelsinkiHelsinkiFinland

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