Regulation of Insulin-Like Growth Factor-1 Gene Expression by Estrogen

  • Liam J. Murphy
  • Henry G. Friesen


Insulin-like growth factor-I (IGF-I) is a polypeptide of 70 amino acids which has structural similarities to proinsulin and relaxin1. In addition to its insulin like actions it is mitogenic for a variety of cultured cells2. jhe growth stimulating actions of growth hormone are thought to be mediated at least in part by insulin-like growth factor-I2,3. Expression of IGF-I appears to be GH-dependent in most tissues4,5,6. Since IGF-I is able to mimic the effects of GH in the hypophysectomized rat it has been considered to be a relatively specific mediator of GH action7. More recently other roles for IGF-I have been proposed. These include local growth in response to various stimuli including partial hepatectomy8 and partial nephrectomy9,10. In addition, IGF-I appears to have some role in differentiation of neural tissue11, muscle12 and adipose tissue12 and appears to synergize with other hormones to enhance responsivity14,15. Over the past few years our laboratory has examined the role of IGF-I in estrogen-induced uterine proliferation. Here, we review the evidence that estrogen is the major regulator of uterine IGF-I expression and examine the interaction of estrogen and growth hormone on IGF-I expression in the uterus and liver.


Uterine Response Human Breast Cancer Biopsy Repeated Intraperitoneal Injection 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Liam J. Murphy
    • 1
  • Henry G. Friesen
    • 1
  1. 1.Department of Physiology, Faculty of MedicineUniversity of ManitobaWinnipegCanada

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