Ovarian Insulin-Like Growth Factor I: Basic Concepts Leading to Potential Clinical Outlets

  • Eli Y. Adashi
  • Carol E. Resnick
  • Eleuterio R. Hernandez
  • Marjorie E. Svoboda
  • Judson J. Van Wyk

Abstract

Amongst potential novel intraovarian regulators, insulin-like growth factor I (IGF-I) has been the subject of increasingly intense investigation1. Taken together, these studies strongly suggest the existence of an intraovarian autocrine control mechanism, wherein IGF-I may serve as the central signal, and the granulosa cell its site of production, reception, and action. In doing so, IGF-I may promote the replication and/or cytodifferentiation of the developing granulosa cell, acting largely (but not exclusively) as an amplifier of gonadotropin action. Furthermore, IGF-I (presumptively of granulosa cell origin) may also provide paracrine input to the adjacent theca-interstitial cell compartment in the interest of coordinated follicular development.

Keywords

Cholesterol Estrogen Polypeptide Progesterone Androgen 

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Eli Y. Adashi
    • 1
    • 2
  • Carol E. Resnick
    • 1
    • 2
  • Eleuterio R. Hernandez
    • 1
    • 2
  • Marjorie E. Svoboda
    • 1
    • 2
  • Judson J. Van Wyk
    • 1
    • 2
  1. 1.Division of Reproductive Endocrinology, Department of Obstetrics and GynecologyUniversity of Maryland, School of MedicineBaltimoreUSA
  2. 2.Department of PediatricsUniversity of North Carolina at Chapel HillChapel HillUSA

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