A Possible Mechanism for Increments of Calcium and Protein Kinase C Activity in Kidney of Experimental Acute Fluorosis
Chronic fluoride toxicity has studied in livestock and dental fluorosis. Experimental-induced chronic toxicity in rodents is also associated with nephrotoxicity. In human being, acute toxicity usually occurs as a result of accidental or suicidal ingestion of fluoride, and it results in gastrointestinal effects, severe hypercalcemia, hyperglycemia, nephrotoxicity, and shock (Shupe et al., 1984; Taylor et al., 1961). On the other hand, we found that a single large dose of fluoride (NaF 35 mg/kg, ip) to rats markedly increased the calcium content of the kidney (Suketa et al., 1977, 1986; Suketa and Kanamoto, 1983). Moreover, we demonstrated fluorideinduced hyperglycemia to be due to elevation of cAMP levels in serum, liver and kidney by the fluoride dose (Suketa and Sato, 1980; Suketa et al., 1980, 1982, 1985, 1986).
KeywordsAdenylate Cyclase Calcium Content Brush Border Membrane Dental Fluorosis Renal Calcium
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