Disregulation of Cell Calcium and Calcium-Binding Proteins in Experimental Hypertension

  • Ramachandra M. Rao
  • Eric W. Young
  • David A. McCarron
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 255)


Hypertension in experimental animal models is often associated with several distinct abnormalities in calcium metabolism from the level of the cell to the whole organism. The physiological and biochemical defects in the regulation of calcium include: low serum ionized calcium, elevated serum PTH, hypercalciuria, decreased intestinal calcium absorption, altered vitamin D metabolism, decreased calcium reabsorption, altered membrane- binding, and decreased binding to intracellular calcium-binding proteins. These derangements of systemic and intracellular calcium regulation lead to the overall calcium imbalance best reflected by reduced bone density and bone mineralization.


Experimental Hypertension Hypertensive Animal Intestinal Calcium Transport Calmodulin Level Intracellular Free Calcium Level 


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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Ramachandra M. Rao
    • 1
  • Eric W. Young
    • 1
  • David A. McCarron
    • 1
  1. 1.Division of Nephrology and Hypertension Institute for Nutrition and Cardiovascular ResearchOregon Health Sciences UniversityPortlandUSA

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