Calcium in Mitosis: Role of 51-kD Protein in the Centrosome of Sea Urchin Egg in Aster Formation

  • Hikoichi Sakai
  • Kunihiro Ohta
  • Masaru Toriyama
  • Sachiko Endo
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 255)


It has been proposed that cytoplasmic free calcium is a regulator of many cellular events during cell cycle. Signal transduction in the trigger of cell multiplication includes transient increase in free calcium through the inosital turnover (Berridge & Irvine, 1984; Rozengurt, 1986) similar to a burst of free calcium observed at fertilization of eggs (Whitaker & Steinhardt, 1985). This is probably followed by a variety of chains of reactions towards replication of genomes and construction of mitotic machineries. Since microtubules which are susceptible to calcium have been shown to be main skeletons of the mitotic apparatus, calcium has been proposed as a regulator in mitosis.


Mitotic Spindle Free Calcium Spindle Pole Microtubule Assembly Intracellular Free Calcium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Hikoichi Sakai
    • 1
  • Kunihiro Ohta
    • 1
  • Masaru Toriyama
    • 1
  • Sachiko Endo
    • 1
  1. 1.Department of Biophysics and Biochemistry Faculty of ScienceUniversity of TokyoHongo, Tokyo 113Japan

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