Advertisement

Regulation of Embryonic Smooth Muscle Myosin by Myosin Light Chain Kinase and by Protein Kinase C

  • Primal de Lanerolle
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 255)

Abstract

The presence of developmentally regulated myosin isoforms in muscle tissues is well established (1–9). Cardiac myosin has been studied extensively, and three different isoforms have been identified (4,5). These myosin isoforms differ with respect to (a) their mobilities on nondenaturing Polyacrylamide gels (3), (b) subunit composition (3,4), and (c) actomyosin ATPase activities (4). Moreover, specific cardiac myosin isoforms are expressed following volume overload of the heart (2) and change depending upon thyroid hormone levels (5). Similarly, fiberspecific myosin isoforms are expressed in skeletal muscle, and the myosin isoform correlates with both the type of innervation and the sequence of electrical stimulation (6).

Keywords

Smooth Muscle Myosin Myosin Isoforms Chicken Gizzard Myosin Phosphorylation Dependent ATPase Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    H. Takano-Ohmuro, T. Obinata, M. Kawashima, T. Masaki, and T. Tanaka, Embryonic Chicken Skeletal, Cardiac, and Smooth Muscles Express a Common Embryo-specific Myosin Light Chain. J. Cell Biol. 100:2025–2030 (1985).PubMedCrossRefGoogle Scholar
  2. 2.
    A.M. Lompre, K. Schwartz, A. d’Albis, G. Lacombe, N. Van Thiem, and B. Swynghedauw, Myosin Isoenzyme Redistribution in Chronic Heart Overload. Nature 282:105–107 (1979).PubMedCrossRefGoogle Scholar
  3. 3.
    J.F.Y. Hoh, P.A. McGrath, and R.I. White, Electrophoretic Analysis of Multiple Forms of Myosin in Fast-Twitch and Slow-Twitch Muscles of the Chick. Biochem. J. 157:87–95 (1976).PubMedGoogle Scholar
  4. 4.
    J.J. Schier and R.S. Adelstein, Structural and Enzymatic Comparison of Human Cardiac Muscle Myosins Isolated from Infants, Adults, and Patients with Hypertrophic Cardiomyopathy. J. Clin. Invest. 69:816–825 (1982).PubMedCrossRefGoogle Scholar
  5. 5.
    I.L. Flink, J.H. Rader, and E. Morkin, Thyroid Hormone Stimulates Synthesis of a Cardiac Myosin Isozyme. J. Biol. Chem. 254:3105–3110 (1979).PubMedGoogle Scholar
  6. 6.
    S. Salmons, and F.A. Sreter, Significance of Impulse Activity in the Transformation of Skeletal Muscle Type. Nature 263:30–34 (1976).PubMedCrossRefGoogle Scholar
  7. 7.
    D.A. Winkelmann, S. Lowey, and J.L. Press, Monoclonal Antibodies Localize Changes on Myosin Heavy Chain Isozymes during Avian Myogenesis. Cell 34:295–306 (1983).PubMedCrossRefGoogle Scholar
  8. 8.
    N. Katoh, and S. Kubo, Purfication and Some Properties of Rabbit Stomach Myosin. J. Biochem. 81:1497–1503 (1977).PubMedGoogle Scholar
  9. 9.
    H. Takano-Ohmuro, T. Obinata, T. Mikawa, and T. Masaki, Changes in Myosin Isozymes during Development of Chicken Gizzard Muscle. J. Biochem. 93:903–908 (1983).PubMedCrossRefGoogle Scholar
  10. 10.
    M. Kawashima, Y. Nabeshima, T. Obinata, and Y. Fujii-Kuriyama, A Common Myosin Light Chain is Expressed in Chicken Embryonic Skeletal, Cardiac, and Smooth Muscles and in Brain Continuously from Embryo to Adult. J. Biol. Chem. 262:14408–14414 (1987).PubMedGoogle Scholar
  11. 11.
    R.S. Adelstein and C.B. Klee, Purification and Characterization of Smooth Muscle Myosin Light Chain Kinase. J. Biol. Chem. 256:7501–7509 (1981).PubMedGoogle Scholar
  12. 12.
    M. Nishikawa, S. Shirakawa, and R.S. Adelstein, Phosphorylation of Smooth Muscle Myosin Light Chain Kinase by Protein Kinase C. J. Biol. Chem. 260:8978–8983 (1985).PubMedGoogle Scholar
  13. 13.
    P. de Lanerolle, R.S. Adelstein, J.R. Feramisco, and K. Burridge, Characterization of Antibodies to Smooth Muscle Myosin Kinase and their use in Localizing Myosin Kinase in Nonmuscle Cells. Proc. Natl. Acas. Sci. USA 78:4738–4742 (1981).CrossRefGoogle Scholar
  14. 14.
    D.R. Hathaway and J.R. Haeberle, A Radioimmunoblotting Method for Measuring Myosin Light Chain Phosphorylation Levels in Smooth Muscle. Am. J. Physiol. 249: C345–C351 (1985).PubMedGoogle Scholar
  15. 15.
    J.R. Sellers, M.D. Pato, and R.S. Adelstein, Reversible Phosphorylation of Smooth Muscle Myosin, Heavy Meromyosin, and Platelet Myosin. J. Biol. Chem. 256:13137–13142 (1981).PubMedGoogle Scholar
  16. 16.
    M. Nishikawa, H. Hidaka, and R.S. Adelstein, Phosphorylation of Smooth Muscle Heavy Meromyosin by Calcium-activated, Phospholipid-dependent Protein Kinase. J. Biol. Chem. 258:14069–14072 (1983).PubMedGoogle Scholar
  17. 17.
    J.A. Spudich, and S. Watt, The Regulation of Rabbit Skeletal Muscle Contraction. J. Biol. Chem. 246:1866–1871, (1971).Google Scholar
  18. 18.
    O.H. Lowry, N.J. Rosenbrough, A.L. Farr, and R.J. Randall, Protein Measurement with the Folin Phenol Reagent. J. Biol. Chem. 193:265–275 (1951).PubMedGoogle Scholar
  19. 19.
    U.K. Laemmli, Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4. Nature 227:680–685 (1970).PubMedCrossRefGoogle Scholar
  20. 20.
    P. de Lanerolle, M. Nishikawa, R. Felsen, and R.S. Adelstein, Immunological Properties of Myosin Light-Chain Kinases. Biochimica et Biophysica Acta 914:74–82 (1987).PubMedCrossRefGoogle Scholar
  21. 21.
    J.C. Seidel, N. Nath, and S. Nag, Ca2+ Dependence of the ATPase Activity of Phosphorylated Smooth Muscle Myosin: Effects of Tropomyosin and Actin. Biochimica et Biophysica Acta 871:93–100 (1986).PubMedCrossRefGoogle Scholar
  22. 22.
    M. Ikebe, D.J. Hartshorne, and M. Elzinga, Phosphorylation of the 20,000-Dalton Light Chain of Smooth Muscle Myosin by the Calcium-Activated, Phospholipid-Dependent Protein Kinase. J. Biol. Chem. 262:9569–9573 (1987).PubMedGoogle Scholar
  23. 23.
    P. de Lanerolle, and M. Nishikawa, Regulation of Embryonic Smooth Muscle Myosin by Protein Kinase C. J. Biol. Chem. 263:9071–9074 (1988).PubMedGoogle Scholar
  24. 24.
    R.S. Adelstein, Regulation of Contractile Proteins by Phosphorylation. J. Clin. Invest. 72:1863–1866 (1983).PubMedCrossRefGoogle Scholar
  25. 25.
    P. de Lanerolle, and J.T. Stull, Myosin Phosphorylation during Contraction and Relaxation of Tracheal Smooth Muscle. J. Biol. Chem. 255:9993–10000 (1980).PubMedGoogle Scholar
  26. 26.
    L. Donner, P. de Lanerolle, and J. Costa, Immunoreactivity of Paraffin-embedded Normal Tissues and Mesenchymal Tumors for Smooth Muscle Myosin. Am. J. Clin. Path. 80:677–681 (1983).PubMedGoogle Scholar
  27. 27.
    R.M. Medford, R.M. Wydro, H.T. Nguyen, and B. Nadal-Ginard, Cytoplasmic Processing of Myosin Heavy Chain Messenger RNA: Evidence Provided by using a Recombinant DNA Plasmid. Proc. Natl. Acad. Sci. USA 77:5749–5753 (1980).PubMedCrossRefGoogle Scholar
  28. 28.
    A.R. Bengur, E.A. Robinson, E. Appella, and J.R. Sellers, Sequence of the Sites Phosphorylated by Protein Kinase C in the Smooth Muscle Myosin Light Chain. J. Biol. Chem. 262:7613–7617 (1987).PubMedGoogle Scholar
  29. 29.
    I. Mabuchi, and M. Okuno, The Effect of Myosin Antibody on the Division of Starfish Blastomeres. J. Cell Biol. 74:251–263 (1977).PubMedCrossRefGoogle Scholar
  30. 30.
    D.A. Knecht and W.F. Loomis, Antisense RNA Inactivation of Myosin Heavy Chain Gene Expression in Dictyostelium discoideum. Science 236:1081–1086 (1987).PubMedCrossRefGoogle Scholar
  31. 31.
    A. De Lozanne and J.A. Spudich, Disruption of the Dictyostelium Myosin Heavy Chain Gene by Homologous Recombination. Science 236:1086–1091 (1987).PubMedCrossRefGoogle Scholar
  32. 32.
    Y. Nishizuka, Studies and Perspectives of Protein Kinase C. Science 233:305–312 (1986).PubMedCrossRefGoogle Scholar
  33. 33.
    E. Rozengurt, Early Signals in the Mitogenic Response. Science 234:161–166 (1986).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Primal de Lanerolle
    • 1
  1. 1.Department of Physiology and BiophysicsUniversity of Illinois at ChicagoChicagoUSA

Personalised recommendations