Roles of Protein Kinase C Isozymes in Cellular Regulation

  • Kuo-Ping Huang
  • Freesia L. Huang
  • Hiroki Nakabayashi
  • Yasuyoshi Yoshida
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 255)


The importance of protein kinase C (PKC) in the regulation of cellular function was fully recognized after the discovery of diacylglycerol (DG) as an activator of PKC and that the tumor-promoting phorbol esters elicit their pleiotropic responses through binding to PKC as a phorbol ester receptor (for review see 1, 2). Both DG and phorbol ester stimulate PKC activity by increasing the affinity of the enzyme for Ca2+ and phospholipid so that the enzyme becomes active under the physiological conditions. This hypothetical scheme appears to provide a satisfactory explanation for the activation of PKC inside the cells.


Purkinje Cell Phorbol Ester Visual Information Processing Hydroxylapatite Column PDBu Binding 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Kuo-Ping Huang
    • 1
  • Freesia L. Huang
    • 1
  • Hiroki Nakabayashi
    • 1
  • Yasuyoshi Yoshida
    • 1
  1. 1.Section on Metabolic Regulation, Endocrinology and Reproduction Research BranchNational Institute of Child Health and Human Development, National Institutes of HealthBethesdaUSA

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