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Calcium Protein Signaling pp 21–28Cite as

Roles of Protein Kinase C Isozymes in Cellular Regulation

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 255))

Abstract

The importance of protein kinase C (PKC) in the regulation of cellular function was fully recognized after the discovery of diacylglycerol (DG) as an activator of PKC and that the tumor-promoting phorbol esters elicit their pleiotropic responses through binding to PKC as a phorbol ester receptor (for review see 1, 2). Both DG and phorbol ester stimulate PKC activity by increasing the affinity of the enzyme for Ca2+ and phospholipid so that the enzyme becomes active under the physiological conditions. This hypothetical scheme appears to provide a satisfactory explanation for the activation of PKC inside the cells.

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Author information

Authors and Affiliations

  1. Section on Metabolic Regulation, Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, 20892, USA

    Kuo-Ping Huang, Freesia L. Huang, Hiroki Nakabayashi & Yasuyoshi Yoshida

Authors
  1. Kuo-Ping Huang
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  2. Freesia L. Huang
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  3. Hiroki Nakabayashi
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  4. Yasuyoshi Yoshida
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Editor information

Editors and Affiliations

  1. Nagoya University, Nagoya, Japan

    H. Hidaka

  2. Swiss Federal Institute of Technology, Zurich, Switzerland

    E. Carafoli

  3. Baylor College of Medicine, Houston, Texas, USA

    A. R. Means

  4. Mie University School of Medicine, Mie, Japan

    T. Tanaka

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© 1989 Plenum Press, New York

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Huang, KP., Huang, F.L., Nakabayashi, H., Yoshida, Y. (1989). Roles of Protein Kinase C Isozymes in Cellular Regulation. In: Hidaka, H., Carafoli, E., Means, A.R., Tanaka, T. (eds) Calcium Protein Signaling. Advances in Experimental Medicine and Biology, vol 255. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5679-0_3

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  • DOI: https://doi.org/10.1007/978-1-4684-5679-0_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5681-3

  • Online ISBN: 978-1-4684-5679-0

  • eBook Packages: Springer Book Archive

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