Structural Organization of the Human Parvalbumin Gene
Several genes encoding Ca2+-binding proteins of the EF-hand type have been isolated from different species (for a recent review see1). Many structural features such as splice site positions with respect to the homologous amino acid sequences, are common among these genes. The original hypothesis put forward by Kretsinger2 that EF-hand type Ca2+-binding proteins evolved from a common ancestor by gene duplication could be confirmed by molecular genetic analysis and a better understanding of the genetic diversity was the result of this approach. Based on the intron/exon splice position of the genes for parvalbumin, calmodulin, myosin light chain 1 and 3, Spec1, calbindin and calretinin an evolutionary tree has been recently proposed3.
KeywordsMyosin Light Chain Homologous Amino Acid Sequence Carp Muscle Homologous Promoter Transcription Regulatory Sequence
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