Abstract
Based upon their number of calcium sites, two intracellular vitamin D-regulated calcium-binding proteins, CaBPs, (Calbindin-D9K and 28K) are expressed in specific target organs of the rat (1,2). CaBP9K was first located in the absorptive cells of the duodenum and has two calcium-binding sites. CaBP28K, which is concentrated in the distal tubules of kidney and in specific neurons of the nervous system, has four functional calcium-binding sites. Only the CaBP28K is present in birds and is expressed in the intestine, the kidney and specific neurons of the nervous system. Both CaBP9K and 28K belong to the calciprotein family which includes calmodulin, troponin C, parvalbumin (3). In this family, each Ca-binding site is organized into a consensus structure called by Kretsinger an EF-hand which consists of a helix, a loop and a helix. Calcium is bound to the loop region (3).
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© 1989 Plenum Press, New York
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Perret, C., Lomri, N., Thomasset, M. (1989). Structure of the Rat Vitamin D-Induced Calbindin-D9K Gene and Evolution of the EF-Hand Calcium-Binding Protein Family. In: Hidaka, H., Carafoli, E., Means, A.R., Tanaka, T. (eds) Calcium Protein Signaling. Advances in Experimental Medicine and Biology, vol 255. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5679-0_26
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DOI: https://doi.org/10.1007/978-1-4684-5679-0_26
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