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Neutralization of Surface Charges Markedly Affects the Properties of Bovine Calbindin D9k

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Book cover Calcium Protein Signaling

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 255))

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Abstract

Calbindin D9k constitutes an attractive model system for exploring the relationships between structure, dynamics and function in the EF-hand family of proteins. It is the smallest protein known (Mr ≈ 8,500; 75 a.a:s) with a pair of EF-hand Ca2+-binding sites and its structure resembles closely the globular domains of the homologous proteins calmodulin, parvalbumin and skeletal muscle troponin C. [1,7]. The schematic structure of calbindin is shown in Fig. 1.

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References

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Author information

Authors and Affiliations

  1. Physical Chemistry2, Chemical Centre, Lund University, P.O. Box 124, S-221 00, Lund, Sweden

    S. Forsén, M. Akke, T. Drakenberg, C. Johansson, S. Linse & E. Thulin

  2. Unit of Appl. Cell and Molecular Biology, Umeå University, S-901 87, Umeå, Sweden

    P. Brodin & T. Grundström

  3. Div. of Physical Biochemistry, Natl. Institute for Medical Research, Mill Hill, London, NW7 1AA, England

    P. Bayley & S. Martin

Authors
  1. S. Forsén
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  2. M. Akke
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  3. P. Brodin
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  4. P. Bayley
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  5. T. Drakenberg
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  6. T. Grundström
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  7. C. Johansson
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  8. S. Linse
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  9. S. Martin
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  10. E. Thulin
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Editor information

Editors and Affiliations

  1. Nagoya University, Nagoya, Japan

    H. Hidaka

  2. Swiss Federal Institute of Technology, Zurich, Switzerland

    E. Carafoli

  3. Baylor College of Medicine, Houston, Texas, USA

    A. R. Means

  4. Mie University School of Medicine, Mie, Japan

    T. Tanaka

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© 1989 Plenum Press, New York

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Forsén, S. et al. (1989). Neutralization of Surface Charges Markedly Affects the Properties of Bovine Calbindin D9k . In: Hidaka, H., Carafoli, E., Means, A.R., Tanaka, T. (eds) Calcium Protein Signaling. Advances in Experimental Medicine and Biology, vol 255. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5679-0_20

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  • DOI: https://doi.org/10.1007/978-1-4684-5679-0_20

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5681-3

  • Online ISBN: 978-1-4684-5679-0

  • eBook Packages: Springer Book Archive

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