Calcium Signaling of Calcium-Binding Proteins and Drug Actions
Intracellular calcium ion plays a critical role in cell activation in response to various agonists and calmodulin is a major intracellular receptor for calcium ion. At first, there is the formation of a calcium-calmodulin complex. Subsequently, the calcium-calmodulin complex interact with target proteins. Then, the target protein becomes active and transfer calcium signal to the next molecule. Recently, we have found many calmodulin antagonists with various chemical structures (Figure 1). These compounds selectively inhibit the process of interaction of the calcium-calmodulin complex with target proteins.
KeywordsMast Cell Myosin Light Chain Calcium Binding Protein Myosin Light Chain Kinase Calcium Entry Blocker
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