Activation of Rabbit Skeletal Muscle Myosin Light Chain Kinase by Calmodulin- A Mechanistic Overview

  • Peter J. Kennelly
  • Melissa Starovasnik
  • Edwin G. Krebs
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 255)


The myosin light chain kinases [MLCK, E.C.] are a family of tissue-specific isozymes which share as their substrate the phosphoryl- or P-light chain.component of myosin. Distinct forms of MLCK have been isolated from smooth, skeletal, and cardiac muscle. The enzyme appears to be ubiquitous, with non-muscle MLCK envisaged as being very similar, if not identical, to the smooth muscle isozyme (For a review see (43)).


Myosin Light Chain Kinase Alpha Helix Phosphorylase Kinase Autoinhibitor Domain Partial Proteolysis 


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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Peter J. Kennelly
    • 1
  • Melissa Starovasnik
    • 2
  • Edwin G. Krebs
    • 1
    • 2
    • 3
  1. 1.Howard Hughes Medical InstituteUniversity of WashingtonSeattleUSA
  2. 2.Department of BiochemistryUniversity of WashingtonSeattleUSA
  3. 3.Department of PharmacologyUniversity of WashingtonSeattleUSA

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