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Molecular Properties of Voltage-Sensitive Calcium Channels

  • William A. Catterall
  • Michael J. Seagar
  • Masami Takahashi
  • Kazuo Nunoki
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 255)

Abstract

Voltage sensitive calcium channels participate in action potential generation in electrically excitable cells and constitute an essential link between transient changes in membrane potential and a variety of cellular responses including secretion of neurotransmitters and hormones, initiation of contraction in cardiac and smooth muscle, and activation of second messenger responses in many cell types. Electrophysiological measurements have established the existence of multiple classes of calcium channels.1–4 Although work on many cell systems has contributed to current understanding of calcium channel function, the molecular properties of the channel have been investigated most thoroughly in skeletal muscle which has a particularly high density of calcium channels. This chapter will therefore focus primarily on skeletal muscle calcium channels.

Keywords

Calcium Channel Transverse Tubule Voltage Sensitive Calcium Channel Dihydropyridine Calcium Channel Antagonist Calcium Channel Subunit 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • William A. Catterall
    • 1
  • Michael J. Seagar
    • 1
  • Masami Takahashi
    • 1
  • Kazuo Nunoki
    • 1
  1. 1.Department of Pharmacology, SJ-30University of WashingtonSeattleUSA

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