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Transfer of Human HPRT Gene Sequence into Neuronal Cells by a Herpes Simplex Virus Derived Vector

  • T. D. Palella
  • L. J. Silverman
  • F. L. Homa
  • M. Levine
  • W. N. Kelley
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 253A)

Abstract

The purine salvage enzyme, hypoxanthine-guanine phosphoribosyltrans-ferase (HPRT), catalyzes the conversion of hypoxanthine and guanine to the mononucleotides, IMP and GMP, respectively. Complete deficiency of HPRT activity in humans causes the Lesch-Nyhan syndrome, a devastating disease characterized by overproduction of uric acid and severe neurological dysfunction.1, 2 For a variety of reasons, attention has focused on the Lesch-Nyhan syndrome as one of the initial candidates for therapy by somatic cell gene transfer.3

Keywords

Thymidine Kinase HPRT Activity Human HPRT APRT Gene Herpes Virus Thymidine Kinase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • T. D. Palella
    • 1
  • L. J. Silverman
    • 1
  • F. L. Homa
    • 1
  • M. Levine
    • 1
  • W. N. Kelley
    • 1
  1. 1.Departments of Internal Medicine, Human Genetics and Biological ChemistryUniversity of MichiganAnn ArborUSA

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