Two Types of Mouse FM3A Cell Mutants Deficient in 5-Aminoimidazole-4-Carboxamide Ribonucleotide Transformylase and their Transformants Isolated by Human Chromosome-Mediated Gene Transfer
Purine precursors used in the synthesis of nucleic acids are produced by a well-defined sequence of enzymatic reactions. The characterization of this pathway and its regulation in bacteria and lower eukaryotes has been due, in large part, to the availability of auxotrophic mutants defective in purine biosynthesis.
KeywordsAuxotrophic Mutant Wild Type Line Purine Biosynthesis Major Spot Human Metaphase Chromosome
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