Two Types of Mouse FM3A Cell Mutants Deficient in 5-Aminoimidazole-4-Carboxamide Ribonucleotide Transformylase and their Transformants Isolated by Human Chromosome-Mediated Gene Transfer

  • Dai Ayusawa
  • Masatake Yamauchi
  • Kimiko Shimizu
  • Takeshi Seno
  • Michio Matsuhashi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 253A)


Purine precursors used in the synthesis of nucleic acids are produced by a well-defined sequence of enzymatic reactions. The characterization of this pathway and its regulation in bacteria and lower eukaryotes has been due, in large part, to the availability of auxotrophic mutants defective in purine biosynthesis.


Auxotrophic Mutant Wild Type Line Purine Biosynthesis Major Spot Human Metaphase Chromosome 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Dai Ayusawa
    • 1
  • Masatake Yamauchi
    • 2
  • Kimiko Shimizu
    • 1
  • Takeshi Seno
    • 3
  • Michio Matsuhashi
    • 2
  1. 1.Department of Immunology and VirologySaitama Cancer Center Research InstituteIna-machi, Saitama 362Japan
  2. 2.The Institute of Applied MicrobiologyUniversity of TokyoBunkyou-ku, Tokyo 113Japan
  3. 3.Department of Molecular GeneticsNational Institute of GeneticsMishima, Shizuoka 411Japan

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